Diversification of hepatitis C viruses in South America reveals a novel genetic lineage

Diversification of hepatitis C viruses in South America reveals a novel genetic lineage Hepatitis C virus (HCV) has high genomic variability and, since its discovery, at least six different types and an increasing number of sub-types have been reported. Genotype 1 is the most prevalent genotype found in South America. Recent phylogenetic analysis of strains isolated in Uruguay revealed the presence of a different genetic lineage from major sub-types 1a and 1b. In order to study if type 1 HCV strains circulating in the South American region can be associated with this genetic lineage, sequence data obtained from the 5′ non-coding region from 6 type 1 patients from Chile, were compared with sequences obtained from 12 type 1 Uruguayan and 9 type 1 Brazilian patients as well as 17 different strains of all types isolated elsewhere. The phylogenetic analysis revealed the existence of type 1 strains of this novel genetic lineage in all South American countries studied, and indicates a diversification of HCV viruses in the South American region. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Diversification of hepatitis C viruses in South America reveals a novel genetic lineage

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Publisher
Springer Journals
Copyright
Copyright © 2001 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050170084
Publisher site
See Article on Publisher Site

Abstract

Hepatitis C virus (HCV) has high genomic variability and, since its discovery, at least six different types and an increasing number of sub-types have been reported. Genotype 1 is the most prevalent genotype found in South America. Recent phylogenetic analysis of strains isolated in Uruguay revealed the presence of a different genetic lineage from major sub-types 1a and 1b. In order to study if type 1 HCV strains circulating in the South American region can be associated with this genetic lineage, sequence data obtained from the 5′ non-coding region from 6 type 1 patients from Chile, were compared with sequences obtained from 12 type 1 Uruguayan and 9 type 1 Brazilian patients as well as 17 different strains of all types isolated elsewhere. The phylogenetic analysis revealed the existence of type 1 strains of this novel genetic lineage in all South American countries studied, and indicates a diversification of HCV viruses in the South American region.

Journal

Archives of VirologySpringer Journals

Published: Aug 1, 2001

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