Diabetologia (2017) 60:1761–1769 DOI 10.1007/s00125-017-4327-y ARTICLE Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice 1 1 1 1 1 Shogo Ida & Katsutaro Morino & Osamu Sekine & Natsuko Ohashi & Shinji Kume & 2 3 3 3 1 Tokuhiro Chano & Kanako Iwasaki & Norio Harada & Nobuya Inagaki & Satoshi Ugi & Hiroshi Maegawa Received: 24 December 2016 /Accepted: 18 April 2017 /Published online: 22 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract that O-GlcNAcylation is essential for survival in adult mice. Aims/hypothesis O-GlcNAcylation is characterised by the Tissue-specific Ogt deletion from insulin-sensitive organs, addition of N-acetylglucosamine to various proteins by including liver, skeletal muscle and adipose tissue, had little O-GlcNAc transferase (OGT) and serves in sensing intracel- impact on glucose metabolism under physiological condi- lular nutrients by modulating various cellular processes. tions. However, pancreatic beta cell-specific Ogt-KO mice Although it has been speculated that O-GlcNAcylation is as- displayed transient hypoglycaemia (Ogt-flox 5.46 ± 0.41 vs sociated with glucose metabolism, its exact role in whole body Ogt-βKO 3.88 ± 0.26 mmol/l) associated with about twofold glucose metabolism has not been fully elucidated. Here, we higher insulin secretion and accelerated adiposity,
Diabetologia – Springer Journals
Published: Jun 22, 2017
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