Distribution of the hepatitis B surface antigen subtypes in Indonesia: implications for ethnic heterogeneityand infection control measures

Distribution of the hepatitis B surface antigen subtypes in Indonesia: implications for ethnic... Previous studies on the distribution of subtypes of hepatitis B surface antigen (HBsAg) in Indonesia have not entirely covered the whole nation. Consequently, we determined the HBsAg subtypes, adw, adr, ayw, and ayr in a total of 569 HBsAg-positive sera from areas so far not studied. With results in this and our previous studies taken together (a total of 3045 HBsAg-positive sera were analyzed), a nationwide picture on the HBsAg subtype distribution indicated that Indonesia could roughly be divided into 4 zones: (i) adw -predominant zone consisting of Sumatera, Java, southern part of Kalimantan, Bali, Lombok, Ternate, and Morotai; (ii) ayw -zone of the eastern part of Nusa Tenggara and Moluccas, (iii) adr -zone of Irian Jaya; and (iv) a mixed subtype-zone of Kalimantan, Sulawesi and Sumbawa. An interesting exception was Padang of Sumatera island: Padang was rich in adr although it is far from the adr -zone. Since the HBsAg subtype, like mutations in mitochondrial DNA, could be used as an ethnological marker, our present results suggest that the peoples in Indonesia have at least three major ethnic origins, represented by adw, ayw, and adr . Of another note, the diagnostic and preventive measures for hepatitis B virus (HBV) infection in Indonesia may be improved by considering such diversity of HBV strains revealed in this study. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Distribution of the hepatitis B surface antigen subtypes in Indonesia: implications for ethnic heterogeneityand infection control measures

Loading next page...
 
/lp/springer_journal/distribution-of-the-hepatitis-b-surface-antigen-subtypes-in-indonesia-XqhcI001W0
Publisher
Springer-Verlag
Copyright
Copyright © Wien by 1997 Springer-Verlag/
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050230
Publisher site
See Article on Publisher Site

Abstract

Previous studies on the distribution of subtypes of hepatitis B surface antigen (HBsAg) in Indonesia have not entirely covered the whole nation. Consequently, we determined the HBsAg subtypes, adw, adr, ayw, and ayr in a total of 569 HBsAg-positive sera from areas so far not studied. With results in this and our previous studies taken together (a total of 3045 HBsAg-positive sera were analyzed), a nationwide picture on the HBsAg subtype distribution indicated that Indonesia could roughly be divided into 4 zones: (i) adw -predominant zone consisting of Sumatera, Java, southern part of Kalimantan, Bali, Lombok, Ternate, and Morotai; (ii) ayw -zone of the eastern part of Nusa Tenggara and Moluccas, (iii) adr -zone of Irian Jaya; and (iv) a mixed subtype-zone of Kalimantan, Sulawesi and Sumbawa. An interesting exception was Padang of Sumatera island: Padang was rich in adr although it is far from the adr -zone. Since the HBsAg subtype, like mutations in mitochondrial DNA, could be used as an ethnological marker, our present results suggest that the peoples in Indonesia have at least three major ethnic origins, represented by adw, ayw, and adr . Of another note, the diagnostic and preventive measures for hepatitis B virus (HBV) infection in Indonesia may be improved by considering such diversity of HBV strains revealed in this study.

Journal

Archives of VirologySpringer Journals

Published: Nov 1, 1997

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off