Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river

Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption... The distributions of 31 pharmaceuticals grouped into nine therapeutic classes, including six anticancer drugs, were investigated in the waters and sediments of an urban river in Japan. The coefficients of sorption (logK d) to the river sediments were also determined from the results of a field survey and laboratory-scale experiment. Three anticancer drugs—bicalutamide, doxifluridine, and tamoxifen—were detected in the river sediments at maximum concentrations of 391, 392, and 250 ng/kg, respectively. In addition, the transformation products of psychotropic carbamazepine (2-hydroxy carbamazepine, acridine, and acridone) were detected in the range of 108 ng/kg (2-hydroxy carbamazepine) to 2365 ng/kg (acridine), and the phytoestrogen glycitein was detected in the range of N.D. to 821 ng/kg. The logK d values of the targeted pharmaceuticals in river sediments in the field survey ranged from 0.5 (theophylline) to 3.3 (azithromycin). These results were in accord with those of the laboratory-scale sorption experiment. To the best of our knowledge, this is the first report of the detection of the anticancer drugs bicalutamide and tamoxifen, the transformation products of carbamazepine (2-hydroxy carbamazepine, acridine, and acridone), and the phytoestrogen genistein in river sediments. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Environmental Science and Pollution Research Springer Journals

Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river

Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river

Environ Sci Pollut Res (2017) 24:19021–19030 DOI 10.1007/s11356-017-9525-0 RESEARCH ARTICLE Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river 1 1 1 1 1 Takashi Azuma & Natsumi Arima & Ai Tsukada & Satoru Hirami & Rie Matsuoka & 1 1 1 1 Ryogo Moriwake & Hirotaka Ishiuchi & Tomomi Inoyama & Yusuke Teranishi & 1 1 1 1 1 Misato Yamaoka & Mao Ishida & Kanae Hisamatsu & Ayami Yunoki & Yoshiki Mino Received: 16 January 2017 /Accepted: 12 June 2017 /Published online: 28 June 2017 Springer-Verlag GmbH Germany 2017 . . Abstract The distributions of 31 pharmaceuticals grouped in- Keywords Pharmaceuticals Transformationproducts Solid . . to nine therapeutic classes, including six anticancer drugs, were sample Sorption distribution coefficient (logK ) Ultrasonic investigated in the waters and sediments of an urban river in extraction UPLC-MS/MS Japan. The coefficients of sorption (logK ) to the river sedi- ments were also determined from the results of a field survey and laboratory-scale experiment. Three anticancer drugs— Introduction bicalutamide, doxifluridine, and tamoxifen—were detected in the river sediments at maximum concentrations of 391, 392, Environmental pollution problems caused by the presence of and 250 ng/kg, respectively. In addition, the transformation residual pharmaceuticals in river water environments have products of psychotropic carbamazepine (2-hydroxy been reported worldwide (Evgenidou et al. 2015; Tiedeken carbamazepine, acridine, and acridone) were detected in the et al. 2017; Vasquez et al. 2014). The occurrence and environ- range of 108 ng/kg (2-hydroxy carbamazepine) to 2365 ng/ mental fate of many kinds of pharmaceuticals have been in- kg (acridine), and the phytoestrogen glycitein was detected in vestigated (López-Serna et al. 2013; Oliveira et al. 2015)and the range of N.D. to 821...
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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Environment; Environment, general; Environmental Chemistry; Ecotoxicology; Environmental Health; Atmospheric Protection/Air Quality Control/Air Pollution; Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution
ISSN
0944-1344
eISSN
1614-7499
D.O.I.
10.1007/s11356-017-9525-0
Publisher site
See Article on Publisher Site

Abstract

The distributions of 31 pharmaceuticals grouped into nine therapeutic classes, including six anticancer drugs, were investigated in the waters and sediments of an urban river in Japan. The coefficients of sorption (logK d) to the river sediments were also determined from the results of a field survey and laboratory-scale experiment. Three anticancer drugs—bicalutamide, doxifluridine, and tamoxifen—were detected in the river sediments at maximum concentrations of 391, 392, and 250 ng/kg, respectively. In addition, the transformation products of psychotropic carbamazepine (2-hydroxy carbamazepine, acridine, and acridone) were detected in the range of 108 ng/kg (2-hydroxy carbamazepine) to 2365 ng/kg (acridine), and the phytoestrogen glycitein was detected in the range of N.D. to 821 ng/kg. The logK d values of the targeted pharmaceuticals in river sediments in the field survey ranged from 0.5 (theophylline) to 3.3 (azithromycin). These results were in accord with those of the laboratory-scale sorption experiment. To the best of our knowledge, this is the first report of the detection of the anticancer drugs bicalutamide and tamoxifen, the transformation products of carbamazepine (2-hydroxy carbamazepine, acridine, and acridone), and the phytoestrogen genistein in river sediments.

Journal

Environmental Science and Pollution ResearchSpringer Journals

Published: Jun 28, 2017

References

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