Upon stimulation with lipopolysaccharide, murine RAW264.7 macrophages generated a high amount of nitric oxide. Pretreatment of macrophages with methyl-β-cyclodextrin, which disrupted the lipid raft microdomains of the plasma membrane, inhibited the generation of nitric oxide by down-regulating the expression of inducible nitric oxide synthase. Methyl-β-cyclodextrin exposure significantly inhibited the degradation of IκB-α, blocked the translocation of p65/RelA into the nuclei and prevented the activation of the NF-κB signaling pathway. The results suggest that the expression of inducible nitric oxide synthase and the consequent production of nitric oxide depend on the integrity of the lipid rafts.
Research on Chemical Intermediates – Springer Journals
Published: Jan 1, 2006
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