Generalized tonic–clonic seizure (GTCS) is characterized by the abnormal functional organization among distant brain regions. Previous studies in GTCS that have comprehensively examined connectivity abnormalities across the complete range of large-scale brain networks remain relatively rare. Here, we employed an amount of regions of interest to investigate the intra- and inter-connections among seven large-scale brain networks in GTCS and healthy controls. Network contingency analysis revealed that patients with GTCS exhibit significantly increased connectivity between default mode network (DMN) and frontoparietal network (FPN), between DMN and dorsal attention network, and between somatomotor network and limbic network, and decreased functional connectivity within FPN (all p values were Bonferroni corrected). Consistent with existing evidence, the disrupted functional architecture of the DMN and task-positive network may be related to self-related processes and deficits in cognitive control and attention in patients. These findings support the notion that GTCS is associated with disrupted architecture in large-scale brain networks, providing information for better understanding of the pathophysiological mechanisms of GTCS.
Applied Informatics – Springer Journals
Published: Nov 29, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera