Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?

Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way... Curr Diab Rep (2017) 17: 122 https://doi.org/10.1007/s11892-017-0957-1 GENETICS (AP MORRIS, SECTION EDITOR) Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? 1 1,2 Amélie Bonnefond & Philippe Froguel Published online: 23 October 2017 Springer Science+Business Media, LLC 2017 Abstract understanding of T2D molecular mechanisms, keeping in Purpose of Review Type 2 diabetes (T2D) is a complex ge- mind that melatonin is a versatile hormone and regulates many netic metabolic disorder. T2D heritability has been estimated functions via its primary role in the body clock. around 40–70%. In the last decade, exponential progress has been made in identifying T2D genetic determinants, through . . Keywords Circadian rhythm Clock Expression genome-wide association studies (GWAS). Among single- quantitative trait loci (eQTL) Genome-wide association study nucleotide polymorphisms mostly associated with T2D risk, . . . . (GWAS) Insulin secretion Melatonin MTNR1B rs10830963 is located in the MTNR1B gene, encoding one of Pancreatic beta cell Rare genetic variant the two receptors of melatonin, a neurohormone involved in circadian rhythms. Subsequent studies aiming to disentangle the role of MTNR1B in T2D pathophysiology led to contro- versies. In this review, we will tackle them and will http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Diabetes Reports Springer Journals

Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Diabetes
ISSN
1534-4827
eISSN
1539-0829
D.O.I.
10.1007/s11892-017-0957-1
Publisher site
See Article on Publisher Site

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