Curr Diab Rep (2017) 17: 122 https://doi.org/10.1007/s11892-017-0957-1 GENETICS (AP MORRIS, SECTION EDITOR) Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? 1 1,2 Amélie Bonnefond & Philippe Froguel Published online: 23 October 2017 Springer Science+Business Media, LLC 2017 Abstract understanding of T2D molecular mechanisms, keeping in Purpose of Review Type 2 diabetes (T2D) is a complex ge- mind that melatonin is a versatile hormone and regulates many netic metabolic disorder. T2D heritability has been estimated functions via its primary role in the body clock. around 40–70%. In the last decade, exponential progress has been made in identifying T2D genetic determinants, through . . Keywords Circadian rhythm Clock Expression genome-wide association studies (GWAS). Among single- quantitative trait loci (eQTL) Genome-wide association study nucleotide polymorphisms mostly associated with T2D risk, . . . . (GWAS) Insulin secretion Melatonin MTNR1B rs10830963 is located in the MTNR1B gene, encoding one of Pancreatic beta cell Rare genetic variant the two receptors of melatonin, a neurohormone involved in circadian rhythms. Subsequent studies aiming to disentangle the role of MTNR1B in T2D pathophysiology led to contro- versies. In this review, we will tackle them and will
Current Diabetes Reports – Springer Journals
Published: Oct 23, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera