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/lp/springer_journal/disease-of-mrna-regulation-relevance-for-ischemic-brain-injury-UWXEoimzBn
- Publisher
- Springer Journals
- Copyright
- Copyright © 2017 by Springer Science+Business Media, LLC, part of Springer Nature
- Subject
- Biomedicine; Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery
- ISSN
- 1868-4483
- eISSN
- 1868-601X
- DOI
- 10.1007/s12975-017-0586-7
- pmid
- 29127592
- Publisher site
- See Article on Publisher Site
Abstract
In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.
Journal
Translational Stroke Research – Springer Journals
Published: Nov 10, 2017
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