Disease of mRNA Regulation: Relevance for Ischemic Brain Injury

Disease of mRNA Regulation: Relevance for Ischemic Brain Injury In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Translational Stroke Research Springer Journals

Disease of mRNA Regulation: Relevance for Ischemic Brain Injury

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery
ISSN
1868-4483
eISSN
1868-601X
D.O.I.
10.1007/s12975-017-0586-7
Publisher site
See Article on Publisher Site

Abstract

In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.

Journal

Translational Stroke Research – Springer Journals

Published: Nov 10, 2017

References

  • Translocation of RNA granules in living neurons
    Knowles, RB; Sabry, JH; Martone, ME; Deerinck, TJ; Ellisman, MH; Bassell, GJ
  • Regulation of translation by stress granules and processing bodies
    Kedersha, N; Anderson, P
  • RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules
    Kedersha, NL; Gupta, M; Li, W; Miller, I; Anderson, P
  • Real-time and quantitative imaging of mammalian stress granules and processing bodies
    Kedersha, N; Tisdale, S; Hickman, T; Anderson, P
  • RBPmap: a web server for mapping binding sites of RNA-binding proteins
    Paz, I; Kosti, I; Ares, M; Cline, M; Mandel-Gutfreund, Y
  • Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins
    Harvey, R; Dezi, V; Pizzinga, M; Willis, AE
  • Mechanisms coordinating ELAV/Hu mRNA regulons
    Simone, LE; Keene, JD
  • Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress responses
    Sajjanar, B; Deb, R; Raina, SK; Pawar, S; Brahmane, MP; Nirmale, AV
  • ARED 3.0: the large and diverse AU-rich transcriptome
    Bakheet, T; Williams, BR; Khabar, KS
  • Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
    Fan, XC; Steitz, JA
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
    Mazan-Mamczarz, K; Galban, S; Lopez de Silanes, I; Martindale, JL; Atasoy, U; Keene, JD
  • Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock
    Gallouzi, IE; Brennan, CM; Steitz, JA
  • Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus
    Antic, D; Keene, JD
  • Stress granule assembly is mediated by prion-like aggregation of TIA-1
    Gilks, N; Kedersha, N; Ayodele, M; Shen, L; Stoecklin, G; Dember, LM
  • Stress granules, P-bodies and cancer
    Anderson, P; Kedersha, N; Ivanov, P
  • Cytoplasmic stress granules: dynamic modulators of cell signaling and disease
    Mahboubi, H; Stochaj, U
  • Disturbances of cerebral protein synthesis and ischemic cell death
    Hossmann, KA
  • Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules
    Kayali, F; Montie, HL; Rafols, JA; DeGracia, DJ
  • Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion
    Jamison, JT; Kayali, F; Rudolph, J; Marshall, M; Kimball, SR; DeGracia, DJ
  • Convergence of stress granules and protein aggregates in hippocampal cornu ammonis 1 at later reperfusion following global brain ischemia
    DeGracia, DJ; Rudolph, J; Roberts, GG; Rafols, JA; Wang, J
  • Protein aggregation after transient cerebral ischemia
    Hu, BR; Martone, ME; Jones, YZ; Liu, CL
  • Co-translational protein aggregation after transient cerebral ischemia
    Liu, CL; Ge, P; Zhang, F; Hu, BR
  • Protein aggregation and proteasome dysfunction after brain ischemia
    Ge, P; Luo, Y; Liu, CL; Hu, B
  • Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats
    Truettner, JS; Hu, K; Liu, CL; Dietrich, WD; Hu, B
  • Protein degradation pathways after brain ischemia
    Ge, P; Zhang, F; Zhao, J; Liu, C; Sun, L; Hu, B
  • Stress granule induction after brain ischemia is independent of eukaryotic translation initiation factor (eIF) 2alpha phosphorylation and is correlated with a decrease in eIF4B and eIF4E proteins
    Ayuso, MI; Martinez-Alonso, E; Regidor, I; Alcazar, A
  • Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury
    Jin, K; Li, W; Nagayama, T; He, X; Sinor, AD; Chang, J
  • Microarray analysis of hippocampal gene expression in global cerebral ischemia
    Jin, K; Mao, XO; Eshoo, MW; Nagayama, T; Minami, M; Simon, RP
  • HuR function and translational state analysis following global brain ischemia and reperfusion
    Szymanski, JJ; Wang, H; Jamison, JT; DeGracia, DJ
  • HuD binds to three AU-rich sequences in the 3′-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein
    Cuadrado, A; Navarro-Yubero, C; Furneaux, H; Kinter, J; Sonderegger, P; Munoz, A
  • Acute and persistent protein synthesis inhibition following cerebral reperfusion
    DeGracia, DJ
  • Pathological stress granules in Alzheimer’s disease
    Ash, PE; Vanderweyde, TE; Youmans, KL; Apicco, DJ; Wolozin, B
  • Physiological protein aggregation run amuck: stress granules and the genesis of neurodegenerative disease
    Wolozin, B
  • ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics
    Gal, J; Kuang, L; Barnett, KR; Zhu, BZ; Shissler, SC; Korotkov, KV
  • Interaction of tau with the RNA-binding protein TIA1 regulates tau pathophysiology and toxicity
    Vanderweyde, T; Apicco, DJ; Youmans-Kidder, K; Ash, PEA; Cook, C; Lummertz da Rocha, E
  • Role of stress granules and RNA-binding proteins in neurodegeneration: a mini-review
    Vanderweyde, T; Youmans, K; Liu-Yesucevitz, L; Wolozin, B
  • Control of mRNA translation in ALS Proteinopathy
    Cestra, G; Rossi, S; Salvio, M; Cozzolino, M
  • Protein aggregation after focal brain ischemia and reperfusion
    BR, H; Janelidze, S; Ginsberg, MD; Busto, R; Perez-Pinzon, M; Sick, TJ
  • Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model
    Petrov, T; Underwood, BD; Braun, B; Alousi, SS; Rafols, JA
  • Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury
    Chou, A; Krukowski, K; Jopson, T; Zhu, PJ; Costa-Mattioli, M; Walter, P
  • Reversible induction of TDP-43 granules in cortical neurons after traumatic injury
    Wiesner, D; Tar, L; Linkus, B; Chandrasekar, A; Olde Heuvel, F; Dupuis, L
  • Astrocytic expression of the RNA regulator HuR accentuates spinal cord injury in the acute phase
    Kwan, T; Floyd, CL; Patel, J; Mohaimany-Aponte, A; King, PH
  • Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks
    Beiter, T; Hoene, M; Prenzler, F; Mooren, FC; Steinacker, JM; Weigert, C
  • Emerging role of HuR in inflammatory response in kidney diseases
    Shang, J; Zhao, Z
  • RNA binding protein human antigen R is translocated in astrocytes following spinal cord injury and promotes the inflammatory response
    Kwan, T; Floyd, CL; Kim, S; King, PH
  • Dysregulation of TTP and HuR plays an important role in cancers
    Wang, H; Ding, N; Guo, J; Xia, J; Ruan, Y
  • The chemotherapeutic agent bortezomib induces the formation of stress granules
    Fournier, MJ; Gareau, C; Mazroui, R
  • Raising the bar: how HIF-1 helps determine tumor radiosensitivity
    Moeller, BJ; Dewhirst, MW
  • A novel mechanism of tumor suppression by destabilizing AU-rich growth factor mRNA
    Stoecklin, G; Gross, B; Ming, XF; Moroni, C
  • Rasputin, more promiscuous than ever: a review of G3BP
    Irvine, K; Stirling, R; Hume, D; Kennedy, D
  • HSP70 heat shock gene regulation during ischemia
    Sharp, FR; Kinouchi, H; Koistinaho, J; Chan, PH; Sagar, SM
  • The transcriptome of cerebral ischemia
    VanGilder, RL; Huber, JD; Rosen, CL; Barr, TL
  • Translational control by viral proteinases
    Lloyd, RE
  • Protein kinase R and the inflammasome
    Yim, HC; Williams, BR
  • dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection
    Dabo, S; Meurs, EF
  • Translation inhibition and stress granules in the antiviral immune response
    McCormick, C; Khaperskyy, DA
  • Stress granules in the viral replication cycle
    Montero, H; Trujillo-Alonso, V
  • 1,026 experimental treatments in acute stroke
    O'Collins, VE; Macleod, MR; Donnan, GA; Horky, LL; Worp, BH; Howells, DW
  • Intrinsically disordered proteins in overcrowded milieu: membrane-less organelles, phase separation, and intrinsic disorder
    Uversky, VN
  • Protein aggregation as a mechanism of adaptive cellular responses
    Saarikangas, J; Barral, Y

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