Breast Cancer Res Treat (2018) 168:249–258 https://doi.org/10.1007/s10549-017-4514-z BRIEF REPORT Discordance between oncotype DX recurrence score and RSPC for predicting residual risk of recurrence in ER-positive breast cancer 1,2 3 4 5 • • • • Andrew Dodson David Okonji Laura Assersohn Anne Rigg 6 3 3 3 1,2 • • • • Amna Sheri Nick Turner Ian Smith Marina Parton Mitch Dowsett Received: 9 August 2017 / Accepted: 13 September 2017 / Published online: 11 November 2017 The Author(s) 2017. This article is an open access publication Abstract between RS%-derived categorical risk assignments and Purpose Oncotype DX, a gene expression assay widely treatment recommendation was evaluated. employed to aid decision making on adjuvant chemother- Results Data on 171 tests (168 patients) were available. apy use in patients with primary oestrogen receptor-posi- Median DR risk by RS% was 11% (range 3–34%), by tive (ER?) breast cancer, produces a recurrence score (RS) RSPC it was 15% (range 4–63%). Correlation between related to distant disease recurrence (DR) risk (RS%). In RS% and RSPC was 0.702 (p\ 0.001). RS% classiﬁed node-negative patients, RS can be integrated with clinico- 57.3% of cases as low-, 32.2% intermediate- and 10.5% pathological parameters to derive RS-pathology-clinical high-risk
Breast Cancer Research and Treatment – Springer Journals
Published: Nov 11, 2017
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