Dipstick proteinuria and all-cause mortality among the general population

Dipstick proteinuria and all-cause mortality among the general population Background Dipstick proteinuria, but not albuminuria, is used for general health screening in Japan. How the results of dipstick proteinuria tests correlate with mortality and, however, is not known. Methods Subjects were participants of the 2008 Tokutei-Kenshin (Specific Health Check and Guidance program) in six districts in Japan. On the basis of the national database of death certificates from 2008 to 2012, we used a personal identifier in two computer registries to identify participants who might have died. The hazard ratio (95% confidence interval, CI) was calculated by Cox-proportional hazard analysis. Results Among a total of 140,761 subjects, we identified 1641 mortalities that occurred by the end of 2012. The crude mortality rates were 1.1% for subjects who were proteinuria (−), 1.5% for those with proteinuria (+/−), 2.0% for those with proteinuria (1+), 3.5% for those with proteinuria (2+), and 3.7% for those with proteinuria (≥ 3+). After adjusting for sex, age, body mass index, estimated glomerular filtration rate, comorbid condition, past history, and lifestyle, the hazard ratio (95% CI) for dipstick proteinuria was 1.262 (1.079–1.467) for those with proteinuria (+/−), 1.437 (1.168–1.748) for those with proteinuria (1+), 2.201 (1.688–2.867) for those with proteinuria (2+), and 2.222 (1.418–3.301) for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Experimental Nephrology Springer Journals

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Japanese Society of Nephrology
Subject
Medicine & Public Health; Nephrology; Urology
ISSN
1342-1751
eISSN
1437-7799
D.O.I.
10.1007/s10157-018-1587-x
Publisher site
See Article on Publisher Site

Abstract

Background Dipstick proteinuria, but not albuminuria, is used for general health screening in Japan. How the results of dipstick proteinuria tests correlate with mortality and, however, is not known. Methods Subjects were participants of the 2008 Tokutei-Kenshin (Specific Health Check and Guidance program) in six districts in Japan. On the basis of the national database of death certificates from 2008 to 2012, we used a personal identifier in two computer registries to identify participants who might have died. The hazard ratio (95% confidence interval, CI) was calculated by Cox-proportional hazard analysis. Results Among a total of 140,761 subjects, we identified 1641 mortalities that occurred by the end of 2012. The crude mortality rates were 1.1% for subjects who were proteinuria (−), 1.5% for those with proteinuria (+/−), 2.0% for those with proteinuria (1+), 3.5% for those with proteinuria (2+), and 3.7% for those with proteinuria (≥ 3+). After adjusting for sex, age, body mass index, estimated glomerular filtration rate, comorbid condition, past history, and lifestyle, the hazard ratio (95% CI) for dipstick proteinuria was 1.262 (1.079–1.467) for those with proteinuria (+/−), 1.437 (1.168–1.748) for those with proteinuria (1+), 2.201 (1.688–2.867) for those with proteinuria (2+), and 2.222 (1.418–3.301) for

Journal

Clinical and Experimental NephrologySpringer Journals

Published: Jun 5, 2018

References

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