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Dimethyl fumarate

Dimethyl fumarate Reactions 1704, p139 - 2 Jun 2018 dimethyl fumarate initiation, the absolute lymphocyte count (ALC) was 1350 n/µL. Eventually, she developed prolonged lymphopenia with low ALC, which led to discontinuation of dimethyl fumarate. She had received dimethyl fumarate for Lymphopenia: 5 case reports 12 months. The subsequent laboratory tests showed ALC, In a case series, five patients (one man and four women) WBC and absolute neutrophil count between 500–740 n/µL, aged 36 64 years were described, who developed prolonged 4200–5990 n/µL and 3100–3800 n/µL, respectively. At a lymphopenia during treatment with dimethyl fumarate [route 6-month follow-up, lymphopenia persisted. and dosage not stated; not all times to reaction onsets stated]. Author comment: "Lymphopenia was evaluated as a Case 1: This report describes a 36-year-old woman, who probable iatrogenic complication of [dimethyl fumarate]." developed lymphopenia during treatment with dimethyl "Haematological assessment excluded other causes of fumarate. The woman was diagnosed with relapsing-remitting lymphopenia, which was evaluated as a probable iatrogenic multiple sclerosis (RRMS) in 2001 at the age of 22-year and complication of [dimethyl fumarate]". "Five of these, including received treatment with interferon β-1a until a spinal relapse in the case above, showed prolonged lymphopenia after 2015. At the age of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Dimethyl fumarate

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Dimethyl fumarate

Abstract

Reactions 1704, p139 - 2 Jun 2018 dimethyl fumarate initiation, the absolute lymphocyte count (ALC) was 1350 n/µL. Eventually, she developed prolonged lymphopenia with low ALC, which led to discontinuation of dimethyl fumarate. She had received dimethyl fumarate for Lymphopenia: 5 case reports 12 months. The subsequent laboratory tests showed ALC, In a case series, five patients (one man and four women) WBC and absolute neutrophil count between 500–740 n/µL, aged 36 64 years...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46782-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p139 - 2 Jun 2018 dimethyl fumarate initiation, the absolute lymphocyte count (ALC) was 1350 n/µL. Eventually, she developed prolonged lymphopenia with low ALC, which led to discontinuation of dimethyl fumarate. She had received dimethyl fumarate for Lymphopenia: 5 case reports 12 months. The subsequent laboratory tests showed ALC, In a case series, five patients (one man and four women) WBC and absolute neutrophil count between 500–740 n/µL, aged 36 64 years were described, who developed prolonged 4200–5990 n/µL and 3100–3800 n/µL, respectively. At a lymphopenia during treatment with dimethyl fumarate [route 6-month follow-up, lymphopenia persisted. and dosage not stated; not all times to reaction onsets stated]. Author comment: "Lymphopenia was evaluated as a Case 1: This report describes a 36-year-old woman, who probable iatrogenic complication of [dimethyl fumarate]." developed lymphopenia during treatment with dimethyl "Haematological assessment excluded other causes of fumarate. The woman was diagnosed with relapsing-remitting lymphopenia, which was evaluated as a probable iatrogenic multiple sclerosis (RRMS) in 2001 at the age of 22-year and complication of [dimethyl fumarate]". "Five of these, including received treatment with interferon β-1a until a spinal relapse in the case above, showed prolonged lymphopenia after 2015. At the age of

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

References

  • Severe multiple sclerosis reactivation during prolonged lymphopenia after dimethyl fumarate discontinuation.
    Zecca, C