Differentiation of Furanocoumarin Isomers with Ratio of Relative Abundance of Characteristic Fragment Ions and Application in Angelicae dahuricae Radix

Differentiation of Furanocoumarin Isomers with Ratio of Relative Abundance of Characteristic... Chromatographia (2017) 80:1401–1410 DOI 10.1007/s10337-017-3348-5 ORIGINAL Differentiation of Furanocoumarin Isomers with Ratio of Relative Abundance of Characteristic Fragment Ions and Application in Angelicae dahuricae Radix 1 1 1 1 1 Yulu Tian  · Rui Shi  · Meng Gao  · Hongxia Wang  · Yingfeng Du  · 1 1,2 3 Lantong Zhang  · Qiao Wang  · Min Zhang   Received: 5 April 2017 / Revised: 21 June 2017 / Accepted: 30 June 2017 / Published online: 27 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract C-5-substituted and C-8-substituted furanocou- where M and N represent the ratios of relative abundance of marin isomers, two important kinds of furanocoumarin, characteristic fragment ions of a pair of furanocoumarin iso- are widely documented as the main active constituents in mers. For R value greater than 1, compound M is substituted Angelicae dahuricae radix. Due to the similar polarity and at C-5, whereas for R value less than 1, compound M is sub- mass fragmentation pathways of such isomers, it is diffi - stituted at C-8. This method with good repeatability was cult to distinguish them using mass spectrometric methods. applied to identify five pairs of isomeric furanocoumarins in To address this issue, we developed a strategy employ- Angelicae dahuricae radix. This is the first method to distin - ing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chromatographia Springer Journals

Differentiation of Furanocoumarin Isomers with Ratio of Relative Abundance of Characteristic Fragment Ions and Application in Angelicae dahuricae Radix

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Chemistry; Chromatography; Proteomics; Pharmacy; Laboratory Medicine; Analytical Chemistry
ISSN
0009-5893
eISSN
1612-1112
D.O.I.
10.1007/s10337-017-3348-5
Publisher site
See Article on Publisher Site

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