Chromatographia (2017) 80:1401–1410 DOI 10.1007/s10337-017-3348-5 ORIGINAL Differentiation of Furanocoumarin Isomers with Ratio of Relative Abundance of Characteristic Fragment Ions and Application in Angelicae dahuricae Radix 1 1 1 1 1 Yulu Tian · Rui Shi · Meng Gao · Hongxia Wang · Yingfeng Du · 1 1,2 3 Lantong Zhang · Qiao Wang · Min Zhang Received: 5 April 2017 / Revised: 21 June 2017 / Accepted: 30 June 2017 / Published online: 27 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract C-5-substituted and C-8-substituted furanocou- where M and N represent the ratios of relative abundance of marin isomers, two important kinds of furanocoumarin, characteristic fragment ions of a pair of furanocoumarin iso- are widely documented as the main active constituents in mers. For R value greater than 1, compound M is substituted Angelicae dahuricae radix. Due to the similar polarity and at C-5, whereas for R value less than 1, compound M is sub- mass fragmentation pathways of such isomers, it is diffi - stituted at C-8. This method with good repeatability was cult to distinguish them using mass spectrometric methods. applied to identify five pairs of isomeric furanocoumarins in To address this issue, we developed a strategy employ- Angelicae dahuricae radix. This is the first method to distin - ing
Chromatographia – Springer Journals
Published: Jul 27, 2017
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