Curr HIV/AIDS Rep (2017) 14:123–132 DOI 10.1007/s11904-017-0361-0 CENTRAL NERVOUS SYSTEM AND COGNITION (SS SPUDICH, SECTION EDITOR) Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer’s Disease: an Emerging Issue in Geriatric NeuroHIV 1 1 Benedetta Milanini & Victor Valcour Published online: 5 August 2017 Springer Science+Business Media, LLC 2017 . . . Abstract Keywords HIV HAND Alzheimer’s disease Cognitive . . Purpose of Review The purpose of this review was to examine impairment Biomarkers Neurodegeneration characteristics that may distinguish HIV-associated neurocognitive disorder (HAND) from early Alzheimer’sdis- ease (AD). Introduction Recent Findings Cerebrospinal fluid (CSF) AD biomarkers are perturbed in HIV, yet these alterations may be limited to In 2012, over one quarter of people living with HIV in the settings of advanced dementia or unsuppressed plasma HIV USA were above the age of 55 years . By 2017, these older RNA. Neuropsychological testing will require extensive bat- HIV-infected patients will turn 60 years, entering an age where teries to maximize utility. Structural imaging is limited for Alzheimer’s disease (AD) becomes a critical diagnostic dif- early AD detection in the setting of HIV, but proper studies ferential underlying their cognitive impairment. Given known are absent. While positron-emission tomography (PET) amy- parkinsonian features for
Current HIV/AIDS Reports – Springer Journals
Published: Aug 5, 2017
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