Int Urol Nephrol (2017) 49:1681–1689 DOI 10.1007/s11255-017-1602-2 NEPHROLOGY – ORIGINAL PAPER Differential expression of circulating miR‑21, miR‑142‑3p and miR‑155 in renal transplant recipients with impaired graft function 1 2 3 Sepideh Zununi Vahed · Ahmad Poursadegh Zonouzi · Hossein Ghanbarian · 4 5 6 1 Morteza Ghojazadeh · Nasser Samadi · Yadollah Omidi · Mohammadreza Ardalan Received: 30 January 2017 / Accepted: 17 April 2017 / Published online: 28 April 2017 © Springer Science+Business Media Dordrecht 2017 Abstract controls (N = 15). The possible correlation between clinical Background The discovery of circulating microRNAs parameters and the circulating miRNAs and the receiver- (miRNAs), as potential noninvasive diagnostic biomarkers, operating characteristic (ROC) analysis were performed. has opened new avenues of research for identifying patients Results Our results showed that expression of miR- with chronic failure in renal transplantation. The present 21 (p = 0.023), miR-142-3p (p = 0.048) and miR-155 study aimed to investigate the expression levels of four (p = 0.005) was significantly upregulated in plasma sam - immune-related miRNAs (miR-21, miR-31, miR-142-3p ples of recipients with IFTA in comparison with SGF and and miR-155) in plasma samples of renal recipients. healthy control groups. Concentration of miR-21 (∆ Ct Methods
International Urology and Nephrology – Springer Journals
Published: Apr 28, 2017
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