Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats

Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine... Psychopharmacology (2017) 234:2517–2523 DOI 10.1007/s00213-017-4641-6 ORIGINAL INVESTIGATION Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats 1 1 1 2 Amir H. Rezvani & Susan Slade & Corinne Wells & Venkata M. Yenugonda & 2 2 3 2 1 Yong Liu & Milton L. Brown & Yingxian Xiao & Kenneth J. Kellar & Edward D. Levin Received: 22 November 2016 /Accepted: 26 April 2017 /Published online: 29 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract abstinence, whereas chronic administration of YL-2-203 at the Rationale and objectives Desensitization of neuronal nicotin- same doses was not found to be effective. ic acetylcholine receptors holds promise as an effective treat- Conclusions These studies, together with our previous studies ment of tobacco addiction. Previously, we found that of Saz-A, revealed a spectrum of efficacies for these α4β2 sazetidine-A (Saz-A), which selectively desensitizes α4β2 nicotinic receptor desensitizing agents and provide a path for- nicotinic receptors, significantly decreased intravenous (IV) ward for the most effective compounds to be further devel- nicotine self-administration (SA) in rats with an effective dose oped as possible aids to smoking cessation. of 3 mg/kg in acute and repeated injection studies. We also found that chronic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4641-6
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2517–2523 DOI 10.1007/s00213-017-4641-6 ORIGINAL INVESTIGATION Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats 1 1 1 2 Amir H. Rezvani & Susan Slade & Corinne Wells & Venkata M. Yenugonda & 2 2 3 2 1 Yong Liu & Milton L. Brown & Yingxian Xiao & Kenneth J. Kellar & Edward D. Levin Received: 22 November 2016 /Accepted: 26 April 2017 /Published online: 29 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract abstinence, whereas chronic administration of YL-2-203 at the Rationale and objectives Desensitization of neuronal nicotin- same doses was not found to be effective. ic acetylcholine receptors holds promise as an effective treat- Conclusions These studies, together with our previous studies ment of tobacco addiction. Previously, we found that of Saz-A, revealed a spectrum of efficacies for these α4β2 sazetidine-A (Saz-A), which selectively desensitizes α4β2 nicotinic receptor desensitizing agents and provide a path for- nicotinic receptors, significantly decreased intravenous (IV) ward for the most effective compounds to be further devel- nicotine self-administration (SA) in rats with an effective dose oped as possible aids to smoking cessation. of 3 mg/kg in acute and repeated injection studies. We also found that chronic

Journal

PsychopharmacologySpringer Journals

Published: May 29, 2017

References

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