Psychopharmacology (2017) 234:2463–2473 DOI 10.1007/s00213-017-4636-3 ORIGINAL INVESTIGATION Differential effects of pair housing on voluntary nicotine consumption: a comparison between male and female adolescent rats 1 1 1 1 Hyunchan Lee & Minji Jang & Woonhee Kim & Jihyun Noh Received: 26 November 2016 /Accepted: 24 April 2017 /Published online: 15 May 2017 Springer-Verlag Berlin Heidelberg 2017 . . . Abstract Keywords Adolescence Self-administration Social tie . . Rationale Tobacco smoking occurs in a wide array of social Mice Social reward Social buffering circumstances. Social support for quitting is generally used to stop smoking, while peer interactions may be a crucial factor in triggering tobacco use among adolescents. Introduction Objectives To determine the role of social factors on nicotine dependence, we compared single- and pair-housed rats sub- Nicotine intake facilitates further nicotine consumption, jected to voluntary oral nicotine consumption tests. which leads to addiction among tobacco users (Stead et al. Methods Six-week-old adolescent rats were subjected to ex- 2008). The effects of nicotine that establish and maintain perimental procedures and assigned to one of the following tobacco-related habits result not only from prolonged stimu- groups: a male single group, a male pair group with a sibling, a lation of brain
Psychopharmacology – Springer Journals
Published: May 15, 2017
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