Differential changes in the expression level of M-Cadherin in denervation and reinnervation processes following nerve injury

Differential changes in the expression level of M-Cadherin in denervation and reinnervation... The localization and the expression level of M-cadherin in skeletal muscle was investigated following nerve injury. The rats used in the study, in which the sciatic nerves were cut, were divided into two groups; the nerve was sutured (sutured group) or not sutured (unsutured group). In both groups, the level of M-cadherin expression decreased after the first postoperative week. The decreased level returned to the control level in the sutured group, but it did not return to the control level in the unsutured group. Immunofluorescence staining was observed around the muscular membrane at the 9th, 12th, 16th, 20th, and 24th postoperative weeks in the sutured group. These results suggest that M-cadherin plays a role in maintaining intercellular adhesion around the muscular membrane. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Differential changes in the expression level of M-Cadherin in denervation and reinnervation processes following nerve injury

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag
Subject
Medicine
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-004-0702-2
Publisher site
See Article on Publisher Site

Abstract

The localization and the expression level of M-cadherin in skeletal muscle was investigated following nerve injury. The rats used in the study, in which the sciatic nerves were cut, were divided into two groups; the nerve was sutured (sutured group) or not sutured (unsutured group). In both groups, the level of M-cadherin expression decreased after the first postoperative week. The decreased level returned to the control level in the sutured group, but it did not return to the control level in the unsutured group. Immunofluorescence staining was observed around the muscular membrane at the 9th, 12th, 16th, 20th, and 24th postoperative weeks in the sutured group. These results suggest that M-cadherin plays a role in maintaining intercellular adhesion around the muscular membrane.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Mar 1, 2005

References

  • M-cadherin and its sisters in development of striated muscle
    Kaufmann, U; Martin, B; Link, D; Witt, K; Zeiter, R; Reinhard, S; Starzinski, PA

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