Differential Activity of Superoxide Dismutase Inhibitor in Human Cells under the Action of Radiation, Chemical Mutagens, and upon Radioadaptive Response

Differential Activity of Superoxide Dismutase Inhibitor in Human Cells under the Action of... The superoxide dismutase (SOD) inhibitor, TRIEN, which enhanced the formation of γ-induced DNA breaks in cells of healthy donors and patients with Marfan syndrome and Bloom syndrome (repair-defective hereditary diseases), had virtually no effect on the formation of radioadaptive response (RAR) in these systems. Similar results were obtained in studies on cell survival: TRIEN facilitated mortality in cells irradiated with γ-rays but did not affect RAR formation. TRIEN also increased the deleterious effect of CdCl2, which indicates that SOD apparently plays a certain role in cell defence against this mutagen. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Differential Activity of Superoxide Dismutase Inhibitor in Human Cells under the Action of Radiation, Chemical Mutagens, and upon Radioadaptive Response

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/B:RUGE.0000009151.38425.bf
Publisher site
See Article on Publisher Site

Abstract

The superoxide dismutase (SOD) inhibitor, TRIEN, which enhanced the formation of γ-induced DNA breaks in cells of healthy donors and patients with Marfan syndrome and Bloom syndrome (repair-defective hereditary diseases), had virtually no effect on the formation of radioadaptive response (RAR) in these systems. Similar results were obtained in studies on cell survival: TRIEN facilitated mortality in cells irradiated with γ-rays but did not affect RAR formation. TRIEN also increased the deleterious effect of CdCl2, which indicates that SOD apparently plays a certain role in cell defence against this mutagen.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 7, 2004

References

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