Different trends of transmitted HIV-1 drug resistance in Madrid, Spain, among risk groups in the last decade

Different trends of transmitted HIV-1 drug resistance in Madrid, Spain, among risk groups in the... The presence of transmitted HIV drug resistance (TDR) threatens the efficacy of antiretroviral treatment. We aimed to assess the changes in TDR prevalence over the last decade in Madrid, Spain, to verify the role of the patients’ risk groups in these changes. We analysed the trends of TDR between 2000 and 2011 in a cohort of 1,022 naïve HIV-infected patients in Madrid, Spain, whose pol sequences were available. They included, among others, 369 heterosexuals, 340 men who have sex with men (MSM), and 90 injection drug users (IDUs). TDR was reported following the WHO mutation list. The TDR rate in the whole cohort was 8.3 %, being the highest in MSM (9.1 %) and the lowest in IDUs (4.4 %). Over time, this rate decreased significantly (to 5.4 % in 2009-2011) since the period 2004-2006, when it peaked (10.7 %). Heterosexuals and IDUs showed similar trends, but in the 2009-2011 period, the TDR rate among MSM rebounded to 9.0 % (being absent among IDUs). TDR stabilized in the last years (2007-2011) for nucleoside reverse transcriptase inhibitors. The risk group also determined differences in the mutational profile, sex distribution, proportion of immigrants, and viral variants. In conclusion, the risk group caused different HIV sub-epidemics, determined by the patients’ profiles. Despite the general decreasing trend in TDR, we observed a non-significant increase in TDR rate among MSM, a tendency that needs confirmation. Periodic TDR surveillance is important to prevent the widespread distribution of resistance, especially in MSM, given the growing HIV/AIDS epidemic in this high-risk population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Different trends of transmitted HIV-1 drug resistance in Madrid, Spain, among risk groups in the last decade

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1933-y
Publisher site
See Article on Publisher Site

References

  • Phylogenetic and demographic characterization of HIV-1 transmission in Madrid, Spain
    Yebra, G; Holguín, Á; Pillay, D; Hué, S
  • Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010
    Colafigli, M; Torti, C; Trecarichi, EM; Albini, L; Rosi, A; Micheli, V; Manca, N; Penco, G; Bruzzone, B; Punzi, G
  • Analysis of transmitted drug resistance in Spain in the years 2007-2010 documents a decline in mutations to the non-nucleoside drug class
    Monge, S; Guillot, V; Álvarez, M; Peña, A; Viciana, P; García-Bujalance, S; Pérez-Elías, MJ; Iribarren, JA; Gutiérrez, F; Itziar-Casado, M
  • The calibrated population resistance tool: standardized genotypic estimation of transmitted HIV-1 drug resistance
    Gifford, RJ; Liu, TF; Rhee, SY; Kiuchi, M; Hue, S; Pillay, D; Shafer, RW

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