Different effects of ferulic acid and tetramethylpyrazine on the production of superoxide anion and nitric oxide in murine macrophages

Different effects of ferulic acid and tetramethylpyrazine on the production of superoxide anion... The effects of ferulic acid and tetramethylpyrazine, two active ingredients of the Chinese herbal medicineLigusticum wallichii Franchat, on the generation of superoxide anion and nitric oxide in macrophages were studied. Ferulic acid, but not tetramethylpyrazine, scavenges superoxide anion dose-dependently. Tetramethylpyrazine inhibits the expression of the iNOS gene, and consequently decreases the formation of nitric oxide. However, ferulic acid shows no effect on iNOS expression and NO production. The results suggest that the protective effects of extracts ofLigusticum wallichi Franchat against ischemic injury might be due to the scavenging of superoxide anion and the regulation of NO production. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Different effects of ferulic acid and tetramethylpyrazine on the production of superoxide anion and nitric oxide in murine macrophages

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Publisher
Brill Academic Publishers
Copyright
Copyright © 2004 by 2004 VSP
Subject
Chemistry; Inorganic Chemistry; Physical Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/1568567041570348
Publisher site
See Article on Publisher Site

Abstract

The effects of ferulic acid and tetramethylpyrazine, two active ingredients of the Chinese herbal medicineLigusticum wallichii Franchat, on the generation of superoxide anion and nitric oxide in macrophages were studied. Ferulic acid, but not tetramethylpyrazine, scavenges superoxide anion dose-dependently. Tetramethylpyrazine inhibits the expression of the iNOS gene, and consequently decreases the formation of nitric oxide. However, ferulic acid shows no effect on iNOS expression and NO production. The results suggest that the protective effects of extracts ofLigusticum wallichi Franchat against ischemic injury might be due to the scavenging of superoxide anion and the regulation of NO production.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 9, 2004

References

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