Drugs - Real World Outcomes (2017) 4:167–173 DOI 10.1007/s40801-017-0115-8 ORIGINAL RESEARCH ARTICLE Differences in Adverse Drug Events Among Pediatric Patients With and Without Cancer: Sub-Analysis of a Retrospective Cohort Study 1 2 1 1 • • • • Akira Koizumi Yoshinori Ohta Mio Sakuma Rika Okamoto 1 3,4 1 • • Chisa Matsumoto David W. Bates Takeshi Morimoto Published online: 4 August 2017 The Author(s) 2017. This article is an open access publication Abstract patients and 289 ADEs among 213 non-cancer patients (7.1 Objectives This study investigated the differences in the per patient vs. 0.25 per patient, respectively; p\ 0.0001). incidence and severity of adverse drug events (ADEs) in The most common medications associated with ADEs in pediatric patients with and without cancer. cancer patients were antitumor agents; in contrast, medi- Methods We used data from the Japan Adverse Drug cations associated with fatal or life-threatening ADEs in Events Study for pediatrics, a cohort study enrolling cancer patients were most often sedatives (25%) and blood pediatric inpatients at two tertiary care teaching hospitals in products (25%). Medications associated with fatal or life- Japan. ADEs were identiﬁed by on-site review of all threatening ADEs among non-cancer patients were most medical
Drugs - Real World Outcomes – Springer Journals
Published: Aug 4, 2017
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