ISSN (print) 1869-3482
ISSN (online) 1869-3474
Difference in F-18 FDG Uptake After
Esophagogastroduodenoscopy and Colonoscopy in Healthy
Received: 23 June 2016 /Revised: 26 October 2016 / Accepted: 28 October 2016 / Published online: 21 November 2016
Korean Society of Nuclear Medicine 2016
Purpose We aimed to evaluate the difference in
fluorodeoxyglucose (FDG) uptake in sedated healthy subjects
after they underwent esophagogastroduodenoscopy (EGD)
and colonoscopy procedures.
Methods The endoscopy group (n = 29) included healthy sub-
jects who underwent screening via F-18 FDG positron emis-
sion tomography/computed tomography (PET/CT) after an
EGD and/or colonoscopy under sedation on the same day.
The control group (n = 35) included healthy subjects who
underwent screening via PET/CT only. FDG uptake in the
tongue, uvula, epiglottis, vocal cords, esophagus, stomach,
duodenum, liver, cecum, colon, anus, and muscle were com-
pared between the two groups.
Results Maximum standardized uptake value (SUVmax) in
the tongue, pharynx, larynx, and esophagus did not
significantly differ between the endoscopy and control groups.
In contrast, mean SUVmax in the whole stomach was 18 %
higher in the endoscopy group than in the control group
(SUVmax: 2.96 vs. 2.51, P = 0.010). In the lower gastrointes-
tinal track, SUVmax from the cecum to the rectum was not
significantly different between the two groups, whereas
SUVmax in the anus was 20 % higher in the endoscopy group
than in the control group (SUVmax: 4.21 vs. 3.50, P =0.002).
SUVmax in the liver and muscle was not significantly differ-
ent between the two groups. Mean volume of the stomach and
mean cross section of the colon was significantly higher in the
endoscopy group than in the control group (stomach:
vs. 209.93 cm
, P <0.001, colon: 8.82 cm
, P =0.001).
Conclusions EGD and colonoscopy under sedation does not
lead to significant differences in SUVmax in most parts of the
body. Only gastric FDG uptake in the EGD subjects and anal
FDG uptake in the colonoscopy subjects was higher than up-
take in those regions in the control subjects.
F-18 fluorodeoxyglucose positron emission tomography/
computed tomography (F-18 FDG PET/CT) has become a
crucial imaging method for monitoring patients with malig-
nancies. Malignant tissues have high metabolic rates and can
take up more FDG than normal tissues. However, tissues af-
fected by inflammation or other stress also show enhanced
FDG utilization, which can lead to false-positive results on
PET/CT scans. Surgery, chemotherapy, radiotherapy, or other
interventional procedures can induce unwanted FDG uptake
Electronic supplementary material The online version of this article
(doi:10.1007/s13139-016-0460-7) contains supplementary material,
which is available to authorized users.
* Hyundae Yoon
Department of Nuclear Medicine, Raphael Hospital,
Daegu, Republic of Korea
Department of Nuclear Medicine, Fatima Hospital, Daegu, Republic
Department of Internal Medicine, Raphael Hospital, 303,
Jungang-daero, Jung-gu, 41968 Daegu, Republic of Korea
Department of Surgery, Raphael Hospital, Daegu, Republic of Korea
Department of Anesthesiology, Raphael Hospital, Daegu, Republic
Department of Pathology, Raphael Hospital, Daegu, Republic
Nucl Med Mol Imaging (2017) 51:240–246