Eur J Nutr (2018) 57:83–94 https://doi.org/10.1007/s00394-016-1299-5 ORIGINAL CONTRIBUTION Dietary Salba (Salvia hispanica L.) ameliorates the adipose tissue dysfunction of dyslipemic insulin‑resistant rats through mechanisms involving oxidative stress, inflammatory cytokines and peroxisome proliferator‑activated receptor γ 1 2 1 2 1 M. R. Ferreira · S. M. Alvarez · P. Illesca · M. S. Giménez · Y. B. Lombardo Received: 8 March 2016 / Accepted: 13 August 2016 / Published online: 26 August 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract TNF-α levels. Chia seeds reversed the decrease in PPARγ Purpose Rats fed a long-term sucrose-rich diet (SRD) protein mass level and increased the n-3/n-6 fatty acids developed adipose tissue dysfunction. In the adipose tis- ratio of membrane phospholipids. Besides, dyslipidemia sue of these SRD-fed rats, the present study analyzed the and insulin sensitivity were normalized. possible beneficial effects of dietary Salba (chia) seeds Conclusion This study provides new information con- in improving or reversing the depletion of antioxidant cerning some mechanisms related to the beneficial effects defenses, changes in pro-inflammatory cytokines and ROS of dietary chia seeds in reversing adipose tissue oxida- production. tive stress and improving the adipose tissue dysfunction Methods Wistar rats were fed a SRD for 3 months.
European Journal of Nutrition – Springer Journals
Published: Aug 26, 2016
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