Eur J Nutr (2018) 57:51–60 https://doi.org/10.1007/s00394-016-1296-8 ORIGINAL CONTRIBUTION Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study 1 2 1 Heather R. Millard · Solomon K. Musani · Daniel T. Dibaba · 3 4 5 Sameera A. Talegawkar · Herman A. Taylor · Katherine L. Tucker · Aurelian Bidulescu Received: 28 October 2015 / Accepted: 11 August 2016 / Published online: 22 August 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract mass (p = 0.0006 for trend across choline quartiles) and Purpose Several mechanisms have been described through with abdominal aortic calcium score. Among all JHS par- which dietary intake of choline and its derivative betaine ticipants, there was a statistically significant inverse asso - may be associated in both directions with subclinical ath- ciation between dietary choline intake and incident stroke, erosclerosis. We assessed the association of dietary intake β = −0.33 (p = 0.04). Betaine intake was associated with of choline and betaine with cardiovascular risk and markers greater risk of incident CHD when comparing the third of subclinical cardiovascular disease. quartile of intake with the lowest quartile of intake (HR Methods
European Journal of Nutrition – Springer Journals
Published: Aug 22, 2016
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