Diazepam/tiapride overdose

Diazepam/tiapride overdose Reactions 1680, p119 - 2 Dec 2017 O S Confusion, cardiac toxicity and drowsiness: case report An 18-year-old girl developed partial confusion, cardiac toxicity and drowsiness following an overdose of tiapride and diazepam for an attempted suicide. The girl presented to the emergency department, three hours after the ingestion of 25 tablets of tiapride, 100mg each (total of 2.5g) and diazepam [amount ingested not stated]. She was admitted to the emergency department, where she was noted to be partially confused and drowsy [duration of ingestion to reactions onset not stated]. The Glasgow coma score was 15. After first gastric evacuation, she was transferred to another hospital; where, subsequent clinical examinations were unremarkable. However, she showed minor biological sign of cardiac toxicity. She was discharged 24 hours later, as she was clinically normal in respect to the partial confusion, cardiac toxicity and drowsiness related with the tiapride and diazepam overdose. Author comment: "When the patient was admitted to the emergency department [. . .] the patient was only partially confused and drowsy." "This case supports the fact that an overdose of tiapride is not associated with serious toxicity." "To conclude, we faced an unsuccessful suicide attempt with tiapride." "This seemed to indicate a single, recent, and probably supratherapeutic dose of diazepam". "The patient exhibited a minor biological sign of cardiac toxicity". Couderc S, et al. Unsuccessful Suicide Attempt With Tiapride. Therapeutic Drug Monitoring 39: 581-583, No. 6, Dec 2017. Available from: URL: http:// doi.org/10.1097/FTD.0000000000000453 - France 803284010 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Diazepam/tiapride overdose

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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