Diazepam

Diazepam Reactions 1704, p136 - 2 Jun 2018 Cognitive decline: case report A 46-year-old man developed cognitive decline during treatment with diazepam [Valium; dosage, duration of treatment to reaction onset and outcome not stated] The man had lower extremity spasticity due to a T8 spinal cord injury. He underwent multiple operations including placement of intrathecal baclofen catheter. In 2015, due to worsening of spasticity, he underwent various intrathecal catheter revisions and laminectomies. However, the spasticity worsened and he received large doses of oral diazepam along with baclofen. Consequently, the administration of diazepam resulted in significant cognitive decline. In late 2016, the man underwent various operations. Later, his therapy with diazepam was stopped after improvement of the spasticity. Author comment: "His high oral [diazepam] intake produced a significant cognitive decline." Bakare AA, et al. Subarachnoid-to-Subarachnoid Shunt for Correction of Nonfunctioning Baclofen Pump in a Severe Case of Chronic Debilitating Post- Spinal Cord Injury Spasticity. World Neurosurgery 110: 26-29, Feb 2018. Available from: URL: http://doi.org/10.1016/j.wneu.2017.10.127 - USA 803323988 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Diazepam

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46779-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p136 - 2 Jun 2018 Cognitive decline: case report A 46-year-old man developed cognitive decline during treatment with diazepam [Valium; dosage, duration of treatment to reaction onset and outcome not stated] The man had lower extremity spasticity due to a T8 spinal cord injury. He underwent multiple operations including placement of intrathecal baclofen catheter. In 2015, due to worsening of spasticity, he underwent various intrathecal catheter revisions and laminectomies. However, the spasticity worsened and he received large doses of oral diazepam along with baclofen. Consequently, the administration of diazepam resulted in significant cognitive decline. In late 2016, the man underwent various operations. Later, his therapy with diazepam was stopped after improvement of the spasticity. Author comment: "His high oral [diazepam] intake produced a significant cognitive decline." Bakare AA, et al. Subarachnoid-to-Subarachnoid Shunt for Correction of Nonfunctioning Baclofen Pump in a Severe Case of Chronic Debilitating Post- Spinal Cord Injury Spasticity. World Neurosurgery 110: 26-29, Feb 2018. Available from: URL: http://doi.org/10.1016/j.wneu.2017.10.127 - USA 803323988 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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