Reactions 1704, p136 - 2 Jun 2018
Cognitive decline: case report
A 46-year-old man developed cognitive decline during
treatment with diazepam [Valium; dosage, duration of
treatment to reaction onset and outcome not stated]
The man had lower extremity spasticity due to a T8 spinal
cord injury. He underwent multiple operations including
placement of intrathecal baclofen catheter. In 2015, due to
worsening of spasticity, he underwent various intrathecal
catheter revisions and laminectomies. However, the spasticity
worsened and he received large doses of oral diazepam along
with baclofen. Consequently, the administration of diazepam
resulted in significant cognitive decline.
In late 2016, the man underwent various operations. Later,
his therapy with diazepam was stopped after improvement of
Author comment: "His high oral [diazepam] intake
produced a significant cognitive decline."
Bakare AA, et al. Subarachnoid-to-Subarachnoid Shunt for Correction of
Nonfunctioning Baclofen Pump in a Severe Case of Chronic Debilitating Post-
Spinal Cord Injury Spasticity. World Neurosurgery 110: 26-29, Feb 2018.
Available from: URL: http://doi.org/10.1016/j.wneu.2017.10.127 -
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