Curr Allergy Asthma Rep (2017) 17:64 DOI 10.1007/s11882-017-0732-z IMMUNOLOGIC/DIAGNOSTIC TESTS IN ALLERGY (M CHAPMAN AND A POMÉS, SECTION EDITORS) Diagnosis of Allergy to Mammals and Fish: Cross-Reactive vs. Specific Markers 1 2 1 Christiane Hilger & Marianne van Hage & Annette Kuehn The Author(s) 2017. This article is an open access publication . . Abstract Keywords Allergy diagnosis Allergen component . . . Purpose of Review Allergen extracts are still widely used in Cross-reactive allergen Cross-sensitization Fish allergy allergy diagnosis as they are regarded as sensitive screening Furry animal allergy tools despite the fact that they may lack some minor allergens. Another drawback of extracts is their low specificity, which is due to the presence of cross-reactive allergens. Progress in Introduction allergen identification has disclosed a number of allergenic molecules of homologous sequence and structure which are Allergy diagnosis is still mainly based on allergen extracts. present in different animal species. This review summarizes Skin prick test solutions as well as the majority of assays used recent advances in mammalian and fish allergen identification for in vitro diagnosis are composed of extracts. They are and focuses on their clinical relevance. relatively easy to produce and although they are difficult
Current Allergy and Asthma Reports – Springer Journals
Published: Aug 22, 2017
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