J Endocrinol Invest (2018) 41:447–454 https://doi.org/10.1007/s40618-017-0770-3 ORIGINAL ARTICLE Diagnosis and treatment of TSH‑secreting adenomas: review of a longtime experience in a reference center 1 1 D. M. Nazato · J. Abucham Received: 8 August 2017 / Accepted: 4 October 2017 / Published online: 11 October 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract levels were high in nearly all patients with TSH-secreting Purpose TSH-secreting pituitary adenomas are among the adenomas and useful in excluding other conditions in the less prevalent pituitary tumors, corresponding to 0.9–1.5% differential diagnosis. Proper indication and interpretation of all pituitary adenomas in surgical series. of simple laboratory tests should be emphasized in medical Methods A series of 11 patients with TSH-secreting and education to improve diagnostic accuracy. cosecreting adenomas diagnosed and treated in the last 25 years in a single center is described. Keywords TSH-secreting pituitary adenoma · Results The mean age at diagnosis was 37 years (range Thyrotropinoma · Pituitary tumors · Hyperthyroidism · 18–80 years; median 23 years); the ratio of male-to-female Central hyperthyroidism patients was similar (6M:5F). Only three patients was the correct diagnosis established shortly after the initial medical evaluation. Other four patients were initially diagnosed with Introduction other pituitary adenomas (prolactinoma, acromegaly, and non-secreting pituitary tumor) and another four diagnosed TSH-secreting pituitary adenomas, also
Journal of Endocrinological Investigation – Springer Journals
Published: Oct 11, 2017
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