Diabetic ketoacidosis and diabetes associated with antipsychotic exposure among a previously diabetes-naive population with schizophrenia: a nationwide nested case–control study

Diabetic ketoacidosis and diabetes associated with antipsychotic exposure among a previously... Aims/hypothesis Diabetic ketoacidosis (DKA) is a potentially tified 28 individuals with DKA, 90 with type 1 diabetes fatal metabolic emergency of both type 1 and type 2 diabetes. and 2140 with type 2 diabetes. These were matched to 137, Although there is a reduced risk of type 1 diabetes in schizo- 410 and 9861 individuals in the control group, respective- phrenia, the incidence of DKA is tenfold higher than that of the ly. Antipsychotic exposure was associated with DKA (OR general population. Thus, we aimed to investigate associations 2.60; 95% CI 1.06, 6.38) and type 2 diabetes (OR 1.64; between exposure to antipsychotic medication (within 3 months 95% CI 1.48, 1.83). A trend towards increased risk of type prior to event) and DKA, type 1 diabetes and type 2 diabetes. 1 diabetes was found but remained insignificant (OR 1.38; We also reported related, clinically relevant outcomes. 95% CI 0.84, 2.29). Diabetes aetiology of DKA was type 1 Methods Using a nested case–control study design, we identi- in eight cases and type 2 in 14 cases. Of the remaining six fied cases of DKA, type 1 diabetes and type 2 diabetes in a cases of DKA, aetiology could not be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Diabetic ketoacidosis and diabetes associated with antipsychotic exposure among a previously diabetes-naive population with schizophrenia: a nationwide nested case–control study

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
D.O.I.
10.1007/s00125-017-4320-5
Publisher site
See Article on Publisher Site

Abstract

Aims/hypothesis Diabetic ketoacidosis (DKA) is a potentially tified 28 individuals with DKA, 90 with type 1 diabetes fatal metabolic emergency of both type 1 and type 2 diabetes. and 2140 with type 2 diabetes. These were matched to 137, Although there is a reduced risk of type 1 diabetes in schizo- 410 and 9861 individuals in the control group, respective- phrenia, the incidence of DKA is tenfold higher than that of the ly. Antipsychotic exposure was associated with DKA (OR general population. Thus, we aimed to investigate associations 2.60; 95% CI 1.06, 6.38) and type 2 diabetes (OR 1.64; between exposure to antipsychotic medication (within 3 months 95% CI 1.48, 1.83). A trend towards increased risk of type prior to event) and DKA, type 1 diabetes and type 2 diabetes. 1 diabetes was found but remained insignificant (OR 1.38; We also reported related, clinically relevant outcomes. 95% CI 0.84, 2.29). Diabetes aetiology of DKA was type 1 Methods Using a nested case–control study design, we identi- in eight cases and type 2 in 14 cases. Of the remaining six fied cases of DKA, type 1 diabetes and type 2 diabetes in a cases of DKA, aetiology could not be

Journal

DiabetologiaSpringer Journals

Published: Jun 7, 2017

References

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