Journal of Anesthesia (2018) 32:313–315 https://doi.org/10.1007/s00540-018-2509-5 EDITORIAL Shinju Obara Received: 2 February 2018 / Accepted: 12 May 2018 / Published online: 15 May 2018 © Japanese Society of Anesthesiologists 2018 Keywords Dexmedetomidine · General anesthesia · Intraoperative · Pain management Introduction the usefulness of dexmedetomidine as an adjuvant to con- ventional general anesthesia using propofol or inhaled anes- Newly introduced anesthetic agents are sometimes clini- thetics and opioids has been investigated [3, 4]. With the cally used in cases of unapproved indication when the drug’s anesthetic-sparing property of dexmedetomidine, a reduc- mechanisms of action are considered to be reasonable. tion in individual doses of anesthetics is also expected to Dexmedetomidine, a highly selective α-2-adrenoceptor reduce side effects. agonist, has sedative and analgesic effects without respira- In the recent issues of the Journal of Anesthesia, a variety tory depression. In Japan, dexmedetomidine was approved of applications of dexmedetomidine that may possibly be in 2004 as a sedative in patients during and after mechani- clinical workable alternatives have been reported. cal ventilation in the intensive care setting. The frequency of dexmedetomidine use was low immediately after its introduction into clinical practice, which may partly Pretreatment with dexmedetomidine be because its use was limited to up to
Journal of Anesthesia – Springer Journals
Published: May 15, 2018
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