Dexamethasone/ofloxacin Reactions 1680, p117 - 2 Dec 2017 Staphylococcal endophthalmitis: case report A 60-year-old woman developed Staphylococcal endophthalmitis following treatment with dexamethasone [Ozurdex] and ofloxacin [dosages not stated and not all routes stated]. The woman, who had a history of diabetic retinopathy, was diagnosed with diabetic macular oedema (DME). She was advised intravitreal bevacizumab injection in both the eyes. Improvement was observed in left eye with best corrected visual acuity (BCVA) 6/18, but DME in the right eye persisted. Later, she was given intravitreal dexamethasone injection in the right eye under aseptic precautions followed by administration of ofloxacin eye drops 3 times a day for 3 days. After 72 hours, she presented with redness and pain in the right eye. Examination showed conjunctival congestion and hypopyon with inflammatory membrane in the anterior chamber. Grade 4 vitreous opacity with no view of the retina was noted by fundus evaluation. B-scan ultrasonography revealed increase in intravitreal echoes with intact retinochoroidal complex, suggesting vitritis. She was diagnosed with acute endophthalmitis. The woman’s implant from vitreous cavity was removed by pars plana vitrectomy (PPV). During same session combination of tobramycin and vancomycin was administered. Growth of coagulase-negative Staphylococcus was observed on blood agar culture of vitreous sample. The organism was also found to be resistant to ofloxacin and levofloxacin. After operation, she was treated with tobramycin, dexamethasone, gatifloxacin and cycloplegic eye drops. A week after removal of the implant by vitrectomy improvement was noted in BCVA 6/36, but DME persisted. Author comment: "Our case demonstrated that acute endophthalmitis can occur following dexamethasone intravitreal implant." "In conclusion, our case demonstrated that endophthalmitis can occur after intravitreal dexamethasone implant, and postinjection prophylactic antibiotic use could have been a risk factor." Mahalingam P, et al. Drug-resistant coagulase-negative staphylococcal endophthalmitis following dexamethasone intravitreal implant. Indian Journal of Ophthalmology 65: 634-636, No. 7, Jul 2017. Available from: URL: http:// - India 803285077 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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