Development of human olfactory bulbs in prenatal ontogenesis: An immunochistochemical study with markers of presynaptic terminals (anti-SNAP-25, synapsin-I, and synaptophysin)

Development of human olfactory bulbs in prenatal ontogenesis: An immunochistochemical study with... Data on olfactory bulb (OB) development in human fetuses in the stages from the 8th week to birth is provided. Immunohistochemical markers of presynaptic terminals (anti-SNAP-25, synapsin-I, and synaptophysin) were used to evaluate the maturation of the OB. Differentiation of the OB layers begins from the periphery, which indirectly confirms that growth of the olfactory nerve fibers induces not only the anatomical differentiation of the OB but also the differentiation of its functional layers. The sites of the developing glomeruli are revealed using the immunohistochemical procedure prior to the stage in which distinct glomeruli can be identified using a common histological procedure. The OB conductive system demonstrates immunoreactivity with the antibodies to presynaptic proteins at all stages starting with the 10th–11th weeks of fetal development. Four stages of OB development are described. All functional layers of the OB are mature at the 22nd week stage. Further differentiation of the neuroblasts in the OB, including lamina formation of the internal granular layer and the glomerular layer development, and the growth of the OB continue after the 20th–22nd week stage until 38th–40th weeks of fetal development. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I, and synaptophysin at the 38th-40th weeks of prenatal development are fully consistent with those of the adult OB. Complete maturity of the human OB is reached at the 38th–40th week of prenatal development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Development of human olfactory bulbs in prenatal ontogenesis: An immunochistochemical study with markers of presynaptic terminals (anti-SNAP-25, synapsin-I, and synaptophysin)

Loading next page...
 
/lp/springer_journal/development-of-human-olfactory-bulbs-in-prenatal-ontogenesis-an-A8POkdPulz
Publisher
Springer Journals
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360415030054
Publisher site
See Article on Publisher Site

Abstract

Data on olfactory bulb (OB) development in human fetuses in the stages from the 8th week to birth is provided. Immunohistochemical markers of presynaptic terminals (anti-SNAP-25, synapsin-I, and synaptophysin) were used to evaluate the maturation of the OB. Differentiation of the OB layers begins from the periphery, which indirectly confirms that growth of the olfactory nerve fibers induces not only the anatomical differentiation of the OB but also the differentiation of its functional layers. The sites of the developing glomeruli are revealed using the immunohistochemical procedure prior to the stage in which distinct glomeruli can be identified using a common histological procedure. The OB conductive system demonstrates immunoreactivity with the antibodies to presynaptic proteins at all stages starting with the 10th–11th weeks of fetal development. Four stages of OB development are described. All functional layers of the OB are mature at the 22nd week stage. Further differentiation of the neuroblasts in the OB, including lamina formation of the internal granular layer and the glomerular layer development, and the growth of the OB continue after the 20th–22nd week stage until 38th–40th weeks of fetal development. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I, and synaptophysin at the 38th-40th weeks of prenatal development are fully consistent with those of the adult OB. Complete maturity of the human OB is reached at the 38th–40th week of prenatal development.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: May 26, 2015

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off