Development of erythropoiesis in the mouse

Development of erythropoiesis in the mouse Hematopoiesis consists of a small number of stem cells which rise to a progeny of several distinct lineages. Among these, cells of the erythroid lineage emerge early in the mammalian embryo and provide indispensable functions throughout gestation and postnatal life. Knowledge of the existence of two distinct erythroid lineages, traditionally known as primitive and definitive, has more than a century. In the last decade, it has become evident that the ontogeny of erythropoiesis is more complex than a simple two-steps model. This review summarizes the development and differentiation of the erythroid lineage cells during gestation, and also the characteristics of erythropoiesis during the infant stage, discussing which issues remain open and which need further research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Development of erythropoiesis in the mouse

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Publisher
Pleiades Publishing
Copyright
Copyright © 2016 by Pleiades Publishing, Inc.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360416050052
Publisher site
See Article on Publisher Site

Abstract

Hematopoiesis consists of a small number of stem cells which rise to a progeny of several distinct lineages. Among these, cells of the erythroid lineage emerge early in the mammalian embryo and provide indispensable functions throughout gestation and postnatal life. Knowledge of the existence of two distinct erythroid lineages, traditionally known as primitive and definitive, has more than a century. In the last decade, it has become evident that the ontogeny of erythropoiesis is more complex than a simple two-steps model. This review summarizes the development and differentiation of the erythroid lineage cells during gestation, and also the characteristics of erythropoiesis during the infant stage, discussing which issues remain open and which need further research.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Sep 24, 2016

References

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