Int J CARS (2017) 12:1561–1570 DOI 10.1007/s11548-016-1500-6 ORIGINAL ARTICLE Development of digital phantoms based on a ﬁnite element model to simulate low-attenuation areas in CT imaging for pulmonary emphysema quantiﬁcation 1 2 2,3,4 2 Stefano Diciotti · Alessandro Nobis · Stefano Ciulli · Nicholas Landini · 2 5 6 Mario Mascalchi · Nicola Sverzellati · Bernardo Innocenti Received: 18 July 2016 / Accepted: 31 October 2016 / Published online: 12 November 2016 © CARS 2016 Abstract measurements in CT imaging may not be accurate in the Purpose To develop an innovative ﬁnite element (FE) model assessment of real emphysema extent. of lung parenchyma which simulates pulmonary emphysema Conclusions Our model is able to mimic the cluster size dis- on CT imaging. The model is aimed to generate a set of dig- tribution of LAA on CT imaging of subjects with pulmonary ital phantoms of low-attenuation areas (LAA) images with emphysema. The model could be useful to generate standard different grades of emphysema severity. test images and to design physical phantoms of LAA images Methods Four individual parameter conﬁgurations simulat- for the assessment of the accuracy of indexes for the radio- ing different grades of emphysema severity were utilized to
International Journal of Computer Assisted Radiology and Surgery – Springer Journals
Published: Nov 12, 2016
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