J Cancer Res Clin Oncol (2017) 143:1649–1657 DOI 10.1007/s00432-017-2411-9 ORIGINAL ARTICLE – CANCER RESEARCH Development of a novel prognostic signature of long non‑coding RNAs in lung adenocarcinoma 1,2 1,2 3 4 1,2 Shanbo Zheng · Difan Zheng · Chuanpeng Dong · Jiahua Jiang · Juntao Xie · 1,2 1,2 Yihua Sun · Haiquan Chen Received: 21 December 2016 / Accepted: 29 March 2017 / Published online: 13 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract implications of prognostic lncRNAs were analyzed using Objectives Increasing evidence suggests that long non- the KEGG pathway functional enrichment analysis. coding RNAs (lncRNAs) may play a crucial role in many Results We identified eight lncRNAs which had prognos - biological processes in a variety of cancers and serve as the tic association with p value <0.01 in a TCGA lung adeno- basis for many clinical applications including prognostic carcinoma cohort of 478 patients. Then a novel prognos- biomarkers and potential therapeutic targets. The aim of tic signature with the eight lncRNAs was developed using this study is to develop a prognostic lncRNA signature with Cox regression model. Signature high-risk cases had worse RNA-seq data in lung adenocarcinomas. overall survival (OS, median 85.97 vs. 38.34
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 13, 2017
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