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Antibiotic eremomycin and method for its obtaining
- Publisher
- Springer Journals
- Copyright
- Copyright © 2017 by Pleiades Publishing, Inc.
- Subject
- Life Sciences; Biochemistry, general; Microbiology; Medical Microbiology
- ISSN
- 0003-6838
- eISSN
- 1608-3024
- DOI
- 10.1134/S0003683817080026
- Publisher site
- See Article on Publisher Site
Abstract
A multistep random UV mutagenesis of an eremomycin-producing strain Amycolatopsis orientalis VKPM Ac-1125 with rather low productivity (0.5 g/L) and the further selection of the most high-yield mutant strains have resulted in a highly productive E 13-26 strain. After optimization of the fermentation medium by multifactor analysis, the most efficient composition for the fermentation medium was established, %: glycerol, 8; soybean meals, 2.0; MgCl2, 0.02; KH2PO4, 0.02; KNO3, 0.6; CaCl2, 0.3; skim milk powder, 0.46; and glucose, 0.8. The maximum productivity of this strain on the optimized medium reached 3.42 ± 0.17 g/L. Therefore, the obtained strain is considered to be very promising for further use in the selection and development of technology for the large-scale eremomycin production.
Journal
Applied Biochemistry and Microbiology – Springer Journals
Published: Jul 18, 2016