Breast Cancer Res Treat (2017) 165:355–364 DOI 10.1007/s10549-017-4329-y CLINICAL TRIAL Development of a Ki-67-based clinical trial assay for neoadjuvant endocrine therapy response monitoring in breast cancer 1 2 2 3 • • • • Rodrigo Goncalves Katherine DeSchryver Cynthia Ma Yu Tao 2 4 5 5 • • • • Jeremy Hoog Maggie Cheang Erika Crouch Neha Dahiya 5 6 1 7 • • • • Souzan Sanati Michael Barnes Luis Ota ´ vio Zanatta Sarian John Olson 5 8 Donald Craig Allred Matthew J. Ellis Received: 29 May 2017 / Accepted: 1 June 2017 / Published online: 13 June 2017 The Author(s) 2017. This article is an open access publication Abstract Results Discordant scores led to a triage approach where Purpose The recent publication of the ACOSOG Z1031 cases with complex histological features that software trial results demonstrated that Ki-67 proliferation marker- algorithms could not resolve were ﬂagged for visual point based neoadjuvant endocrine therapy response monitoring counting (17%). The ﬁnal Ki-67 scoring approach was run could be used for tailoring the use of adjuvant on T1/2 N0 cases from the P024 and POL trials (N = 58). chemotherapy in ER?HER2-negative breast cancer The percent positive agreement for
Breast Cancer Research and Treatment – Springer Journals
Published: Jun 13, 2017
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