Development and Validation of Dose-Response Relationship for Listeria monocytogenes

Development and Validation of Dose-Response Relationship for Listeria monocytogenes Listeria monocytogenes is a foodborne pathogen internationally and in the U.S. The objective of this work was to develop and validate a dose-response model for infection by this organism. Only animal data was available in the literature. The beta-Poisson dose response model provided good fit to the data, and one of the two data sets was found to be concordant with attack rates noted in human outbreaks. There are differences, however, between the dose-response relationship and endemic illness rates computed from “market basket” surveys of the prevalence of L. monocytogenes. Further work to elucidate the bases for this difference is necessary. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Quantitative Microbiology Springer Journals

Development and Validation of Dose-Response Relationship for Listeria monocytogenes

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Publisher
Kluwer Academic Publishers
Copyright
Copyright © 1999 by Kluwer Academic Publishers
Subject
Environment; Environmental Engineering/Biotechnology
ISSN
1388-3593
eISSN
1572-9923
D.O.I.
10.1023/A:1010080428554
Publisher site
See Article on Publisher Site

Abstract

Listeria monocytogenes is a foodborne pathogen internationally and in the U.S. The objective of this work was to develop and validate a dose-response model for infection by this organism. Only animal data was available in the literature. The beta-Poisson dose response model provided good fit to the data, and one of the two data sets was found to be concordant with attack rates noted in human outbreaks. There are differences, however, between the dose-response relationship and endemic illness rates computed from “market basket” surveys of the prevalence of L. monocytogenes. Further work to elucidate the bases for this difference is necessary.

Journal

Quantitative MicrobiologySpringer Journals

Published: Oct 15, 2004

References

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