Russian Journal of Applied Chemistry, 2013, Vol. 86, No. 9, pp. 1417−1422.
Pleiades Publishing, Ltd., 2013.
Original Russian Text © T.Sh. Khakamov, D.V. Feoktistov, L.A. Badykova, P.G. Kornilaev, R.R. Shavaleev, R.Kh. Mudarisova, 2013, published in Zhurnal
Prikladnoi Khimii, 2013, Vol. 86, No. 9, pp. 1450−1455.
AND POLYMERIC MATERIALS
Development and Study of Modiﬁ ed Film Coatings
with Controlled Transport Properties
T. Sh. Khakamov, D. V. Feoktistov, L. A. Badykova, P. G. Kornilaev,
R. R. Shavaleev, and R. Kh. Mudarisova
Institute of Organic Chemistry, Ufa Scientiﬁ c Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia
Bashkir State Medical University, Ufa, Bashkortostan, Russia
Received July 26, 2013
Abstract—Interaction of citrus pectin with cefotaxime and 4-methyl-5-oxymethyluracyl was studied by
spectrophotometric methods. New ﬁ lm coatings with these medicinal preparations for mesh implants were produced
on the basis of the citrus pectin–polyvinyl alcohol matrix. It was demonstrated that supramolecular formations of
the polymeric formulation affect the transport properties of the ﬁ lms. A high antibacterial activity of ﬁ lm coatings
with cefotaxime was revealed.
The problem of a prolonged release of medicinal
preparations in medicine and, in particular, in surgery is
rather topical and various methods have been used for
its solution [1–2]. One of these consists in development
of new sheaths for mesh polypropylene implants with
controlled release of medicinal preparations. The
sheaths are polymeric ﬁ lms that can be used for dosed
introduction of medicinal preparations.
Of indubitable scientiﬁ c and practical interest
in development of sheaths of this kind are pectin
substances, natural polymeric derivatives of 1,4-α-D-
galacturonic acid, containing partly esteriﬁ ed carboxyl
The polymers used in medicine must satisfy a
number of rather stringent requirements: nontoxicity,
biocompatibility, and high purity and homogeneity.
Pectins satisfy these requirements and, in addition,
exhibit a high physiological activity by themselves ,
including immunomodulatory and antimicrobial effects
. Just this circumstance served as a reason why pectin
is used as a sheath for mesh implants.
However, the rapid solubility of pectin ﬁ lms in water
is factor restricting their application. To improve the
physical characteristics of these ﬁ lms, their modiﬁ cation
with polyvinyl alcohol was performed.
Polyvinyl alcohol (PVA) is widely used at present
as a drug carrier . Addition of a medicinal molecule
to a matrix based on citrus pectin and PVA will make
it possible to obtain such effects as prolonged release,
change in solubility, and lowered toxicity of an
immobilized medicinal preparation. An also important
circumstance is that this matrix is soluble in biological
ﬂ uids of an organism and, the molecular mass of the
polymers used being low, it will be well washed-out
from the organism .
The goal of our study was to develop and examine
polymeric ﬁ lms based on citrus pectin and polyvinyl
alcohol, with controlled release of medicinal preparations,
cefotaxime and 4-methyl-5-oxymethyluracyl.
As objects of study served citrus pectin (CP) with
molecular mass of 162 000 and PVA with molecular
mass of 7200 (content of vinyl acetate units 0.8–2.0%).
WE chose for immobilization the cefotaxime (CFT)