Development and Evaluation of Tri-Functional Immunoliposomes for the Treatment of HER2 Positive Breast Cancer

Development and Evaluation of Tri-Functional Immunoliposomes for the Treatment of HER2 Positive... Pharm Res (2018) 35:95 https://doi.org/10.1007/s11095-018-2365-x RESEARCH PAPER Development and Evaluation of Tri-Functional Immunoliposomes for the Treatment of HER2 Positive Breast Cancer 1 2 1 Tanaya Vaidya & Robert M. Straubinger & Sihem Ait-Oudhia Received: 7 September 2017 /Accepted: 10 February 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT HER2 positive breast cancer cells and deliver chemotherapy, Purpose Trastuzumab combined with Doxorubicin (DOX) and have the potential to improve clinical outcomes. demonstrates significant clinical activity in human epidermal . . growth factor receptor-2 (HER2)-positive breast cancer (BC). KEY WORDS anti-CD3 HER2-positive breast cancer . . However, emergence of treatment resistance and trastuzumab immunoliposomes trastuzumab doxorubicin associated cardiotoxicity remain clinical challenges. In an ef- fort to improve patient outcome, we have developed and eval- uated novel tri-functional immunoliposomes (TFIL) that tar- ABBREVIATIONS get HER2-receptors on BC cells and CD3-receptors on T- BC Breast Cancer lymphocytes, and deliver DOX. CD3 Cluster of Differentiation Receptor Type 3 Methods Trastuzumab (anti-HER2) and OKT-3 (anti-CD3) CTLs Cytotoxic T Lymphocytes antibodies were conjugated to liposomes using a micelle- DOX Doxorubicin transfer method. Cytotoxicity of targeted immunoliposomes HER2 Human Epidermal Growth Factor Receptor Type 2 loaded with DOX was examined in vitro on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Development and Evaluation of Tri-Functional Immunoliposomes for the Treatment of HER2 Positive Breast Cancer

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2365-x
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35:95 https://doi.org/10.1007/s11095-018-2365-x RESEARCH PAPER Development and Evaluation of Tri-Functional Immunoliposomes for the Treatment of HER2 Positive Breast Cancer 1 2 1 Tanaya Vaidya & Robert M. Straubinger & Sihem Ait-Oudhia Received: 7 September 2017 /Accepted: 10 February 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT HER2 positive breast cancer cells and deliver chemotherapy, Purpose Trastuzumab combined with Doxorubicin (DOX) and have the potential to improve clinical outcomes. demonstrates significant clinical activity in human epidermal . . growth factor receptor-2 (HER2)-positive breast cancer (BC). KEY WORDS anti-CD3 HER2-positive breast cancer . . However, emergence of treatment resistance and trastuzumab immunoliposomes trastuzumab doxorubicin associated cardiotoxicity remain clinical challenges. In an ef- fort to improve patient outcome, we have developed and eval- uated novel tri-functional immunoliposomes (TFIL) that tar- ABBREVIATIONS get HER2-receptors on BC cells and CD3-receptors on T- BC Breast Cancer lymphocytes, and deliver DOX. CD3 Cluster of Differentiation Receptor Type 3 Methods Trastuzumab (anti-HER2) and OKT-3 (anti-CD3) CTLs Cytotoxic T Lymphocytes antibodies were conjugated to liposomes using a micelle- DOX Doxorubicin transfer method. Cytotoxicity of targeted immunoliposomes HER2 Human Epidermal Growth Factor Receptor Type 2 loaded with DOX was examined in vitro on

Journal

Pharmaceutical ResearchSpringer Journals

Published: Mar 13, 2018

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