Pharm Res (2018) 35: 141 https://doi.org/10.1007/s11095-018-2411-8 RESEARCH PAPER Determining the Effect of pH on the Partitioning of Neutral, Cationic and Anionic Chemicals to Artificial Sebum: New Physicochemical Insight and QSPR Model 1 1 2 1 2,3 Senpei Yang & Lingyi Li & Tao Chen & Lujia Han & Guoping Lian Received: 13 November 2017 /Accepted: 16 April 2018 /Published online: 14 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT result from their electrostatic repulsion to fatty acids. Increase Purpose Sebum is an important shunt pathway for transder- in pH also resulted in a slight decrease of sebum partition of mal permeation and targeted delivery, but there have been neutral chemicals. limited studies on its permeation properties. Here we report a Conclusions Based on the observed pH impact on the sebum- measurement and modelling study of solute partition to arti- water partition of neutral, cationic and anionic compounds, a ficial sebum. new quantitative structure-property relationship (QSPR) Methods Equilibrium experiments were carried out for the model has been proposed. This mathematical model considers sebum-water partition coefficients of 23 neutral, cationic and the hydrophobic interaction and electrostatic interaction as anionic compounds at different pH. the main mechanisms
Pharmaceutical Research – Springer Journals
Published: May 14, 2018
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