Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS)

Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in... B American Society for Mass Spectrometry, 2018 J. Am. Soc. Mass Spectrom. (2018) DOI: 10.1007/s13361-018-1987-x FOCUS: APPLICATION OF PHOTONS AND RADICALS FOR MS: RESEARCH ARTICLE Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS) Conner C. Harper, Andrew G. Elliott, Haw-Wei Lin, Evan R. Williams Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA Abstract. A general method for in situ measure- ments of the energy of individual ions trapped and weighed using charge detection mass spectrometry (CDMS) is described. Highly charged (> 300 e), individual polyethylene glycol (PEG) ions are trapped and oscillate within an electrostatic trap, producing a time domain signal. A segmented Fou- rier transform (FT) of this signal yields the temporal evolution of the fundamental and harmonic frequen- cies of ion motion throughout the 500-ms trap time. The ratio of the fundamental frequency and second harmonic (HAR) depends on the ion energy, which is an essential parameter for measuring ion mass in CDMS. This relationship is calibrated using simulated ion signals, and the calibration is compared to the HAR values measured for PEG ion signals where the ion energy was also determined using an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of The American Society for Mass Spectrometry Springer Journals

Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS)

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Publisher
Springer US
Copyright
Copyright © 2018 by American Society for Mass Spectrometry
Subject
Chemistry; Analytical Chemistry; Biotechnology; Organic Chemistry; Proteomics; Bioinformatics
ISSN
1044-0305
eISSN
1879-1123
D.O.I.
10.1007/s13361-018-1987-x
Publisher site
See Article on Publisher Site

Abstract

B American Society for Mass Spectrometry, 2018 J. Am. Soc. Mass Spectrom. (2018) DOI: 10.1007/s13361-018-1987-x FOCUS: APPLICATION OF PHOTONS AND RADICALS FOR MS: RESEARCH ARTICLE Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS) Conner C. Harper, Andrew G. Elliott, Haw-Wei Lin, Evan R. Williams Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA Abstract. A general method for in situ measure- ments of the energy of individual ions trapped and weighed using charge detection mass spectrometry (CDMS) is described. Highly charged (> 300 e), individual polyethylene glycol (PEG) ions are trapped and oscillate within an electrostatic trap, producing a time domain signal. A segmented Fou- rier transform (FT) of this signal yields the temporal evolution of the fundamental and harmonic frequen- cies of ion motion throughout the 500-ms trap time. The ratio of the fundamental frequency and second harmonic (HAR) depends on the ion energy, which is an essential parameter for measuring ion mass in CDMS. This relationship is calibrated using simulated ion signals, and the calibration is compared to the HAR values measured for PEG ion signals where the ion energy was also determined using an

Journal

Journal of The American Society for Mass SpectrometrySpringer Journals

Published: Jun 2, 2018

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