Mammalian Genome 10, 410–414 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Determination of the genomic organization of human presenilin 1 by fiber-FISH analysis and restriction mapping of cloned DNA 1 1 1 1 2 1 Jessie Theuns, Marc Cruts, Jurgen Del-Favero, Dirk Goossens, Hans Dauwerse, Anita Wehnert, 2 1 Johan T. den Dunnen, Christine Van Broeckhoven Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB) and Laboratory of Neurogenetics, Born-Bunge Foundation (BBS), University of Antwerp (UIA), Department of Biochemistry, Universiteitsplein 1, B-2610 Antwerpen, Belgium MGC-Department of Human Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands Received: 5 August 1998 / Accepted: 10 December 1998 The presenilin 1 gene (PSEN1) is the most frequently mutated by genetic linkage studies and physical mapping of the candidate gene in familial early-onset Alzheimer’s disease (AD; Cruts et al. region, using yeast artificial chromosome (YAC) clones (Cruts et 1998). AD is the most common form of dementia due to neuro- al. 1995a, 1995b). A minimal YAC clone contig of YACs 788H12, degeneration of the central nervous system. The autosomal dom- 964E2 and 797D11, was identified (Cruts et al. 1995b). When inant form of AD is extremely
Mammalian Genome – Springer Journals
Published: Apr 1, 1999
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