Objectives To develop a convenient and rapid single-kidney CT-GFR technique. Methods One hundred and twelve patients referred for multiphasic renal CT and 99mTc-DTPA renal dynamic imaging Gates- GFR measurement were prospectively included and randomly divided into two groups of 56 patients each: the training group and the validation group. On the basis of the nephrographic phase images, the fractional renal accumulation (FRA) was calculated and correlated with the Gates-GFR in the training group. From this correlation a formula was derived for single-kidney CT-GFR calculation, which was validated by a paired t test and linear regression analysis with the single-kidney Gates-GFR in the validation group. Results In the training group, the FRA (x-axis) correlated well (r =0.95, p < 0.001) with single-kidney Gates-GFR (y-axis), producing a regression equation of y = 1665x + 1.5 for single-kidney CT-GFR calculation. In the validation group, the difference between the methods of single-kidney GFR measurements was 0.38 ± 5.57 mL/min (p = 0.471); the regression line is identical to the diagonal (intercept = 0 and slope = 1) (p =0.727 and p = 0.473, respectively), with a standard deviation of residuals of 5.56 mL/min. Conclusion A convenient and rapid single-kidney CT-GFR technique was presented
European Radiology – Springer Journals
Published: Feb 9, 2018
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