Determination of dopamine by exploiting the catalytic effect of hemoglobin–stabilized gold nanoclusters on the luminol–NaIO4 chemiluminescence system

Determination of dopamine by exploiting the catalytic effect of hemoglobin–stabilized gold... Hemoglobin–stabilized gold nanoclusters (Hb–AuNCs) were prepared by using hemoglobin as both reducing and stabilizing agents. The Hb–AuNCs display a strong catalytic effect on the chemiluminescence (CL) reaction of luminol with NaIO4. The CL mechanism is discussed and the experimental variables are examined. It is found that dopamine strongly inhibits CL. This finding is exploited in a CL–based dopamine assay that works in the range between 0.3 and 9.0 nM and has a 0.1 nM detection limit. The relative standard deviation is 3.1% at a 5 nM dopamine level (for n = 11). The method was applied to the determination of dopamine in spiked human plasma with satisfactory results. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Microchimica Acta Springer Journals

Determination of dopamine by exploiting the catalytic effect of hemoglobin–stabilized gold nanoclusters on the luminol–NaIO4 chemiluminescence system

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Publisher
Springer Vienna
Copyright
Copyright © 2017 by Springer-Verlag GmbH Austria
Subject
Chemistry; Nanochemistry; Nanotechnology; Characterization and Evaluation of Materials; Analytical Chemistry; Microengineering
ISSN
0026-3672
eISSN
1436-5073
D.O.I.
10.1007/s00604-017-2374-1
Publisher site
See Article on Publisher Site

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