Determination of Aromatic Microbial Metabolites in Blood Serum by Gas Chromatography–Mass Spectrometry

Determination of Aromatic Microbial Metabolites in Blood Serum by Gas Chromatography–Mass... We present the results of the determination of eight aromatic microbial metabolites, phenylcarboxylic acids (PhCAs), by gas chromatography–mass spectrometry after their liquid–liquid extraction from serum samples and derivatization. The analytical range for the analytes is 0.5–40 μM. The concentration of phenylcarboxylic acids in the serum of healthy donors (n = 40) and the time profile of the concentration of different PhCAs in serum samples of four patients from the intensive care unit (ICU) are studied. The results correlated with the severity of the clinical state of patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Analytical Chemistry Springer Journals

Determination of Aromatic Microbial Metabolites in Blood Serum by Gas Chromatography–Mass Spectrometry

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Publisher
Pleiades Publishing
Copyright
Copyright © 2018 by Pleiades Publishing, Ltd.
Subject
Chemistry; Analytical Chemistry
ISSN
1061-9348
eISSN
1608-3199
D.O.I.
10.1134/S1061934818020089
Publisher site
See Article on Publisher Site

Abstract

We present the results of the determination of eight aromatic microbial metabolites, phenylcarboxylic acids (PhCAs), by gas chromatography–mass spectrometry after their liquid–liquid extraction from serum samples and derivatization. The analytical range for the analytes is 0.5–40 μM. The concentration of phenylcarboxylic acids in the serum of healthy donors (n = 40) and the time profile of the concentration of different PhCAs in serum samples of four patients from the intensive care unit (ICU) are studied. The results correlated with the severity of the clinical state of patients.

Journal

Journal of Analytical ChemistrySpringer Journals

Published: Mar 12, 2018

References

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