Determination of 3,4-dihydroxyphenylacetic acid in the presence of ascorbic acid and uric acid at poly(p-aminobenzene sulfonic acid) conducting polymer electrode

Determination of 3,4-dihydroxyphenylacetic acid in the presence of ascorbic acid and uric acid at... Poly(p-aminobenzene sulfonic acid) [poly(p-ABSA)] modified glassy carbon electrode (GCE) was used for the simultaneous determination of ascorbic acid (AA), 3,4-dihydroxyphenylacetic acid (DOPAC) and uric acid (UA). The polymer film was grown on GCE by the cyclic voltammetry method in the potential range from −1.5 to +2.5 V at a scan rate of 50 mV s−1 for 14 cycles in 0.1 M KCl solution containing 5 mM p-ABSA. The anodic peaks for AA, DOPAC and UA at the poly(p-ABSA)/GCE were resolved in phosphate buffer solution (pH 7.0). On the other hand, the electro-oxidation peak current of AA, DOPAC and UA showed linear dynamic range, good stability and sensitivity. The linear range of DOPAC is over four orders of magnitude (R 2 = 0.998). The detection limit of DOPAC is 2.96 × 10−7 mol L−1. The proposed method and electrode have been successfully applied for the determination of DOPAC in urine and blood serum samples and pharmaceutical tablets, demonstrating the stability and reliability of the proposed method and electrode. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Polymer Bulletin Springer Journals

Determination of 3,4-dihydroxyphenylacetic acid in the presence of ascorbic acid and uric acid at poly(p-aminobenzene sulfonic acid) conducting polymer electrode

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Organic Chemistry
ISSN
0170-0839
eISSN
1436-2449
D.O.I.
10.1007/s00289-017-1957-7
Publisher site
See Article on Publisher Site

Abstract

Poly(p-aminobenzene sulfonic acid) [poly(p-ABSA)] modified glassy carbon electrode (GCE) was used for the simultaneous determination of ascorbic acid (AA), 3,4-dihydroxyphenylacetic acid (DOPAC) and uric acid (UA). The polymer film was grown on GCE by the cyclic voltammetry method in the potential range from −1.5 to +2.5 V at a scan rate of 50 mV s−1 for 14 cycles in 0.1 M KCl solution containing 5 mM p-ABSA. The anodic peaks for AA, DOPAC and UA at the poly(p-ABSA)/GCE were resolved in phosphate buffer solution (pH 7.0). On the other hand, the electro-oxidation peak current of AA, DOPAC and UA showed linear dynamic range, good stability and sensitivity. The linear range of DOPAC is over four orders of magnitude (R 2 = 0.998). The detection limit of DOPAC is 2.96 × 10−7 mol L−1. The proposed method and electrode have been successfully applied for the determination of DOPAC in urine and blood serum samples and pharmaceutical tablets, demonstrating the stability and reliability of the proposed method and electrode.

Journal

Polymer BulletinSpringer Journals

Published: Feb 28, 2017

References

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