Eur J Clin Pharmacol (2017) 73:1187–1194 DOI 10.1007/s00228-017-2288-1 PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Determinants of change in polypharmacy status in Switzerland: the population-based CoLaus study 1 1 1 1 Nazanin Abolhassani & Julien Castioni & Pedro Marques-Vidal & Peter Vollenweider & Gérard Waeber Received: 5 April 2017 /Accepted: 12 June 2017 /Published online: 21 June 2017 Springer-Verlag GmbH Germany 2017 Abstract obesity, smoking, previously diagnosed hypertension, or dia- Objectives This study aimed to assess the prevalence, the betes or dyslipidemia were significantly and independently change, and the determinants of change in polypharmacy in associated with initiating and maintaining polypharmacy. a population-based sample. Conclusion In a population-based sample, prevalence of Methods Baseline (2003–2006) and follow-up (2009–2012) polypharmacy doubled over a 5.6-year period. The main de- data are from 4679 participants aged between 35 and 75 years terminants of initiating polypharmacy were age, overweight (53.5% women, mean age 52.6 ± 10.6 years) from the popu- and obesity, smoking status, and previously diagnosed cardio- lation of Lausanne, Switzerland. Polypharmacy was defined vascular risk factors. by the regular use of ≥5 drugs.Four categoriesofchangewere defined: never (no polypharmacy at baseline and follow-up), . . . Keywords Polypharmacy Determinants Trends General initiating (no polypharmacy at baseline but
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 21, 2017
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