Dr. Donald L. Morton was clearly the pioneer of the sentinel node biopsy, which was a major advance in oncology that has improved the management of cancer patients worldwide. He conducted a series of practice-changing clinical trials to validate the important staging role of the sentinel lymph node biopsy for melanoma, and also spawned other studies that demonstrated its staging value in multiple other cancer types, most notably in breast cancer, gastric cancer, and colorectal cancer. His many contributions in this field have provided a unique opportunity to study host/tumor relationships, since the sentinel lymph node is the first location were the host immune defenses are confronted with metastasis arising from the primary cancer. Keywords Detection · Sentinel node biopsy · Melanoma · Clinical trials · Staging It is an honor for me to give the Donald L. Morton Memo- of critical steps inherent to the development of this proce- rial Lecture at the 7th international Symposium on Cancer dure. Years before, Dr. Morton and his colleagues at UCLA Metastasis. Don Morton was my role model, an invaluable Medical Center developed the first lymphoscintigraphy tech- mentor and research collaborator, and a cherished friend nique using radio-labeled colloidal gold . Dr. Morton at (Fig. 1)
Clinical & Experimental Metastasis – Springer Journals
Published: May 31, 2018
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