Biochem Genet https://doi.org/10.1007/s10528-018-9868-3 ORIGINAL ARTICLE Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle 1 1 1 1 1 1 Yunyun Jin · Qing Yang · Jiayang Gao · Qi Tang · Bo Duan · Ting Yu · 2,3 4 4 1 1 Xinglei Qi · Jiming Liu · Rongmin Wang · Ruihua Dang · Chuzhao Lei · 1 1 Hong Chen · Xianyong Lan Received: 21 September 2017 / Accepted: 31 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Growth traits are complex quantitative traits controlled by numerous candidate genes, and they can be well-evaluated using body measurement traits. As the members of the nicotinamide adenine dinucleotide-dependent family of histone deacetylases, class I sirtuin genes (including SIRT1, SIRT2 and SIRT3) play crucial roles in regulating lipid metabolism, cellular growth and metabolism, suggesting that they are potential candidate genes affecting body measurement traits in animals. Hence, the objective of this work aimed to detect novel insertions/deletions (indels) of SIRT1, SIRT2 and SIRT3 genes in 955 cattle belonging to five breeds, as well as to evaluate their effects on body measurement traits. Herein, the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were
Biochemical Genetics – Springer Journals
Published: Jun 4, 2018
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